C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stenting

Rolf P. Kreutz, Janelle Owens, Jeffrey A. Breall, Deshun Lu, Elisabeth Von Der Lohe, Islam Bolad, Anjan Sinha, David A. Flockhart

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Inflammation is implicated in the progression of coronary artery disease and the molecular processes of inflammation and thrombosis are closely intertwined. Elevated levels of C-reactive protein (CRP) have been associated with an elevated risk of adverse ischaemic events after coronary stenting and hypercoagulability. Heightened whole blood clot strength measured by thrombelastography (TEG) has been associated with adverse ischaemic events after stenting. We intended to examine the relationship of CRP to plasma fibrin clot strength in patients after coronary stenting. Plasma fibrin clot strength was measured by TEG in 54 patients 16-24 h after undergoing elective percutaneous coronary intervention (PCI). Coagulation was induced in citrated plasma by addition of kaolin and CaCl2. Plasma levels of CRP and fibrinogen were measured by enzyme-linked immunoassay. Increasing quartiles of CRP were associated with increasing levels of maximal plasma fibrin clot strength measured by TEG (P < 0.001) and increasing BMI (P = 0.04). Patients in the highest quartile of CRP had significantly higher maximal fibrin clot strength (G) than the patients in the lowest quartile (G: 3438†Š±â€Š623 vs. 2184 ±  576 dyn/cm, P <  0.0001). Fibrinogen concentration was not significantly different across quartiles of CRP (P =  0.97). Patients with established coronary artery disease undergoing coronary stenting who have elevated CRP after PCI exhibit heightened maximal plasma fibrin clot strength as compared with those with low CRP. Thrombotic risk associated with elevated CRP may be linked to procoagulant changes and high tensile fibrin clot strength independent of fibrinogen concentration.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume24
Issue number3
DOIs
StatePublished - Apr 1 2013

Fingerprint

Thrombelastography
Fibrin
C-Reactive Protein
Fibrinogen
Percutaneous Coronary Intervention
Coronary Artery Disease
Thrombosis
Inflammation
Kaolin
Thrombophilia
Immunoenzyme Techniques

Keywords

  • C-reactive protein
  • clot strength
  • coronary artery disease
  • fibrin
  • thrombelastography

ASJC Scopus subject areas

  • Hematology

Cite this

C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stenting. / Kreutz, Rolf P.; Owens, Janelle; Breall, Jeffrey A.; Lu, Deshun; Lohe, Elisabeth Von Der; Bolad, Islam; Sinha, Anjan; Flockhart, David A.

In: Blood Coagulation and Fibrinolysis, Vol. 24, No. 3, 01.04.2013, p. 321-326.

Research output: Contribution to journalArticle

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AU - Lohe, Elisabeth Von Der

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