C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease

Taihung Duong, Maria Nikolaeva, Paul J. Acton

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

C-reactive protein (CRP) is a plasma acute-phase protein, normally not found in the brain. Previous studies have demonstrated the presence of CRP in the senile plaques of Alzheimer's disease (AD). In this study, the presence of CRP-like immunoreactivity in AD neurofibrillary tangles (NFT) was demonstrated following pre-treatment of tissue sections with formic acid. CRP-like immunoreactivity was observed in both extracellular and intracellular NFT and was co-localized with the NFT marker PHF-1 and the amyloid P component (AP). The CRP-like immunoreactive NFT were less numerous and more limited in their distribution than PHF-1 or AP-immunoreactive NFT. The present results further support an involvement of inflammatory processes in the etiology of AD.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalBrain research
Volume749
Issue number1
DOIs
StatePublished - Feb 21 1997

Keywords

  • Acute-phase
  • Amyloid P component
  • Inflammation
  • Pentraxin
  • PHF-1

ASJC Scopus subject areas

  • Neuroscience(all)

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