C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease

Taihung Duong, Maria Nikolaeva, Paul J. Acton

Research output: Contribution to journalArticle

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Abstract

C-reactive protein (CRP) is a plasma acute-phase protein, normally not found in the brain. Previous studies have demonstrated the presence of CRP in the senile plaques of Alzheimer's disease (AD). In this study, the presence of CRP-like immunoreactivity in AD neurofibrillary tangles (NFT) was demonstrated following pre-treatment of tissue sections with formic acid. CRP-like immunoreactivity was observed in both extracellular and intracellular NFT and was co-localized with the NFT marker PHF-1 and the amyloid P component (AP). The CRP-like immunoreactive NFT were less numerous and more limited in their distribution than PHF-1 or AP-immunoreactive NFT. The present results further support an involvement of inflammatory processes in the etiology of AD.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalBrain Research
Volume749
Issue number1
DOIs
StatePublished - Feb 21 1997

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Neurofibrillary Tangles
C-Reactive Protein
Alzheimer Disease
Serum Amyloid P-Component
formic acid
Acute-Phase Proteins
Amyloid Plaques
Blood Proteins
Brain

Keywords

  • Acute-phase
  • Amyloid P component
  • Inflammation
  • Pentraxin
  • PHF-1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. / Duong, Taihung; Nikolaeva, Maria; Acton, Paul J.

In: Brain Research, Vol. 749, No. 1, 21.02.1997, p. 152-156.

Research output: Contribution to journalArticle

Duong, Taihung ; Nikolaeva, Maria ; Acton, Paul J. / C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. In: Brain Research. 1997 ; Vol. 749, No. 1. pp. 152-156.
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