Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration

C. V. Fontanilla, Z. Ma, X. Wei, J. Klotsche, L. Zhao, P. Wisniowski, R. C. Dodel, M. R. Farlow, W. H. Oertel, Y. Du

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Parkinson's disease is associated with the loss of dopaminergic neurons in the substantia nigra and decreased striatal dopamine levels. We now report that caffeic acid phenethyl ester (CAPE), an active component of propolis, attenuated dopaminergic neurodegeneration and dopamine loss in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease. The neuroprotective effect of CAPE was associated with marked reductions in inducible nitric oxide synthase (iNOS) and caspase 1 expression. Additionally, CAPE inhibited MPP+-induced neurotoxicity in vitro and directly inhibited MPP+-induced release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria. Thus, CAPE may have beneficial effects in slowing or preventing the progression of Parkinson's disease and other neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalNeuroscience
Volume188
DOIs
StatePublished - Aug 11 2011

Keywords

  • CAPE
  • Mitochondria
  • MPTP
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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    Fontanilla, C. V., Ma, Z., Wei, X., Klotsche, J., Zhao, L., Wisniowski, P., Dodel, R. C., Farlow, M. R., Oertel, W. H., & Du, Y. (2011). Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration. Neuroscience, 188, 135-141. https://doi.org/10.1016/j.neuroscience.2011.04.009