Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury

Xing Wei, Liming Zhao, Zhizhong Ma, David M. Holtzman, Chong Yan, Richard C. Dodel, Harald Hampel, Wolfgang Oertel, Martin Farlow, Yansheng Du

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Neonatal hypoxic-ischaemic (HI) brain injury resulting in encephalopathy is a leading cause of morbidity and mortality with no effective treatment. Here we show that caffeic acid phenethyl ester (CAPE), an active component of propolis, administered either before or after an HI insult, significantly prevents HI-induced neonatal rat brain damage in the cortex, hippocampus and thalamus. In addition to blocking HI-induced caspase 3 activation, CAPE also inhibits HI-mediated expression of inducible nitric oxide synthase and caspase 1 in vivo and potently blocks nitric oxide-induced neurotoxicity in vitro. Furthermore, CAPE directly inhibits Ca2+-induced cytochrome c release from isolated brain mitochondria. Thus, CAPE induces neuroprotection against HI-induced neuronal death, possibly by blocking HI-induced inflammation and/or directly inhibiting the HI-induced neuronal death pathway. CAPE may therefore be a novel effective therapy for preventing neonatal HI injury.

Original languageEnglish
Pages (from-to)2629-2635
Number of pages7
JournalBrain
Volume127
Issue number12
DOIs
StatePublished - Dec 2004

Fingerprint

Brain Injuries
Propolis
Caspase 1
Brain
Brain Diseases
Nitric Oxide Synthase Type II
Cytochromes c
Thalamus
Caspase 3
Hippocampus
Mitochondria
Nitric Oxide
caffeic acid phenethyl ester
Inflammation
Morbidity
Mortality
Wounds and Injuries
Therapeutics

Keywords

  • Brain injury
  • Caffeic acid phenethyl ester
  • Hypoxia-ischaemia
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wei, X., Zhao, L., Ma, Z., Holtzman, D. M., Yan, C., Dodel, R. C., ... Du, Y. (2004). Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain, 127(12), 2629-2635. https://doi.org/10.1093/brain/awh316

Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. / Wei, Xing; Zhao, Liming; Ma, Zhizhong; Holtzman, David M.; Yan, Chong; Dodel, Richard C.; Hampel, Harald; Oertel, Wolfgang; Farlow, Martin; Du, Yansheng.

In: Brain, Vol. 127, No. 12, 12.2004, p. 2629-2635.

Research output: Contribution to journalArticle

Wei, X, Zhao, L, Ma, Z, Holtzman, DM, Yan, C, Dodel, RC, Hampel, H, Oertel, W, Farlow, M & Du, Y 2004, 'Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury', Brain, vol. 127, no. 12, pp. 2629-2635. https://doi.org/10.1093/brain/awh316
Wei X, Zhao L, Ma Z, Holtzman DM, Yan C, Dodel RC et al. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 2004 Dec;127(12):2629-2635. https://doi.org/10.1093/brain/awh316
Wei, Xing ; Zhao, Liming ; Ma, Zhizhong ; Holtzman, David M. ; Yan, Chong ; Dodel, Richard C. ; Hampel, Harald ; Oertel, Wolfgang ; Farlow, Martin ; Du, Yansheng. / Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. In: Brain. 2004 ; Vol. 127, No. 12. pp. 2629-2635.
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