Caffeine ameliorates radiation-induced skin reactions in mice but does not influence tumour radiation response

S. A. Hebbar, Anirban Mitra, K. C. George, N. C. Verma

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Intramuscular administration of caffeine at a dose of 80 mg kg-1 body weight to the gastrocnemius muscles of Swiss mice 5 min prior to local irradiation (35 Gy) of the leg delayed the progression of radiation-induced skin reactions in such animals. While 90% epilation with reddening of the skin was noted in animals treated with radiation alone, animals pretreated with caffeine suffered only partial hair loss with slight reddening of the skin on the 16th and 20th days post-irradiation. Beyond the 28th day, damage scores in irradiated feet for both the groups were similar (score 3) and remained unchanged until the 32nd day and then decreased and disappeared completely in both treatment groups by the 40th day after irradiation. In addition, the effect of caffeine on the radiation response of a mouse fibrosarcoma was investigated. Results showed that intratumoral administration of caffeine at a dose of 80 mg kg-1 body weight 5 min prior to local exposure of tumours to 10 Gy of 60Co γ-rays did not influence the response of tumours to radiation. The present study thus showed that although caffeine ameliorated radiation-induced skin reactions in the mouse leg, it did not affect the tumour radiation response, indicating its potential application in cancer radiotherapy.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of Radiological Protection
Volume22
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

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Caffeine
tumor
Tumors
skin
Skin
Radiation
Neoplasms
irradiation
Animals
Irradiation
animal
Leg
Body Weight
Hair Removal
Fibrosarcoma
Alopecia
Radiotherapy
hair
Dosimetry
Muscle

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Safety, Risk, Reliability and Quality
  • Chemical Health and Safety

Cite this

Caffeine ameliorates radiation-induced skin reactions in mice but does not influence tumour radiation response. / Hebbar, S. A.; Mitra, Anirban; George, K. C.; Verma, N. C.

In: Journal of Radiological Protection, Vol. 22, No. 1, 2002, p. 63-69.

Research output: Contribution to journalArticle

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