Calcified luminal surface area: An improved method to quantify coronary calcification using 3D IVUS analysis

Umesh K. Arora, Ravi Chari, Jeffrey Breall, Daniel J. Diver, Neil J. Weissman

Research output: Contribution to journalArticle

Abstract

The current method of quantifying coronary calcium (CC) with intravascular ultrasound (IVUS) measures the arc of calcium from the 2-dimensional (2D) cross-sectional image at the lesion site. Unfortunately, the 2D method neglects calcification at other sites within the artery and may not adequately represent the degree of total CC. We therefore used a new method, which has previously been pathologically validated, to quantify CC as a percent of the luminal surface area and compared it to the current 2D method. IVUS was performed with a motorized pullback and 2D images were digitized every 1 mm. Total and calcified luminal circumference was measured and, using Simpson's method, the total luminal and calcified luminal surface area was calculated. Standard 2D analysis of calcium arc was performed independently. Results: Pre-interventional IVUS was performed in 41 arteries in 40 pts (33 males, 7 females; 58.3±10.2 years) for a total of 2348 cross-sectional images analyzed. Calcified target lesions were detected in 16/41 coronaries (39%) with an average arc of 79.7±12.0 degrees; 18 of the remaining 25 (72%) had calcium elsewhere. There was no relationship (p=ns) between arc of calcium and either absolute calcified luminal surface area (46.1±45.0 mm2) or relative calcified surface area (7.8±8.0%). 2D calcium quantification underestimated total CC content in 23/40 (58%) pts but paradoxically overestimated calcification in 12 of the 16 (75%) pts with calcified lesions. Conclusions: Presence of lesion calcium does not predict calcification elsewhere nor does its arc adequately quantify the extent of coronary calcification. Calcified luminal surface area is an improved IVUS method that accurately quantifies total arterial calcification.

Original languageEnglish (US)
Pages (from-to)406
Number of pages1
JournalJournal of the American Society of Echocardiography
Volume10
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Calcium
Arteries
Interventional Ultrasonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Calcified luminal surface area : An improved method to quantify coronary calcification using 3D IVUS analysis. / Arora, Umesh K.; Chari, Ravi; Breall, Jeffrey; Diver, Daniel J.; Weissman, Neil J.

In: Journal of the American Society of Echocardiography, Vol. 10, No. 4, 1997, p. 406.

Research output: Contribution to journalArticle

@article{323a722ba83946dab628ad2aef987e14,
title = "Calcified luminal surface area: An improved method to quantify coronary calcification using 3D IVUS analysis",
abstract = "The current method of quantifying coronary calcium (CC) with intravascular ultrasound (IVUS) measures the arc of calcium from the 2-dimensional (2D) cross-sectional image at the lesion site. Unfortunately, the 2D method neglects calcification at other sites within the artery and may not adequately represent the degree of total CC. We therefore used a new method, which has previously been pathologically validated, to quantify CC as a percent of the luminal surface area and compared it to the current 2D method. IVUS was performed with a motorized pullback and 2D images were digitized every 1 mm. Total and calcified luminal circumference was measured and, using Simpson's method, the total luminal and calcified luminal surface area was calculated. Standard 2D analysis of calcium arc was performed independently. Results: Pre-interventional IVUS was performed in 41 arteries in 40 pts (33 males, 7 females; 58.3±10.2 years) for a total of 2348 cross-sectional images analyzed. Calcified target lesions were detected in 16/41 coronaries (39{\%}) with an average arc of 79.7±12.0 degrees; 18 of the remaining 25 (72{\%}) had calcium elsewhere. There was no relationship (p=ns) between arc of calcium and either absolute calcified luminal surface area (46.1±45.0 mm2) or relative calcified surface area (7.8±8.0{\%}). 2D calcium quantification underestimated total CC content in 23/40 (58{\%}) pts but paradoxically overestimated calcification in 12 of the 16 (75{\%}) pts with calcified lesions. Conclusions: Presence of lesion calcium does not predict calcification elsewhere nor does its arc adequately quantify the extent of coronary calcification. Calcified luminal surface area is an improved IVUS method that accurately quantifies total arterial calcification.",
author = "Arora, {Umesh K.} and Ravi Chari and Jeffrey Breall and Diver, {Daniel J.} and Weissman, {Neil J.}",
year = "1997",
language = "English (US)",
volume = "10",
pages = "406",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Calcified luminal surface area

T2 - An improved method to quantify coronary calcification using 3D IVUS analysis

AU - Arora, Umesh K.

AU - Chari, Ravi

AU - Breall, Jeffrey

AU - Diver, Daniel J.

AU - Weissman, Neil J.

PY - 1997

Y1 - 1997

N2 - The current method of quantifying coronary calcium (CC) with intravascular ultrasound (IVUS) measures the arc of calcium from the 2-dimensional (2D) cross-sectional image at the lesion site. Unfortunately, the 2D method neglects calcification at other sites within the artery and may not adequately represent the degree of total CC. We therefore used a new method, which has previously been pathologically validated, to quantify CC as a percent of the luminal surface area and compared it to the current 2D method. IVUS was performed with a motorized pullback and 2D images were digitized every 1 mm. Total and calcified luminal circumference was measured and, using Simpson's method, the total luminal and calcified luminal surface area was calculated. Standard 2D analysis of calcium arc was performed independently. Results: Pre-interventional IVUS was performed in 41 arteries in 40 pts (33 males, 7 females; 58.3±10.2 years) for a total of 2348 cross-sectional images analyzed. Calcified target lesions were detected in 16/41 coronaries (39%) with an average arc of 79.7±12.0 degrees; 18 of the remaining 25 (72%) had calcium elsewhere. There was no relationship (p=ns) between arc of calcium and either absolute calcified luminal surface area (46.1±45.0 mm2) or relative calcified surface area (7.8±8.0%). 2D calcium quantification underestimated total CC content in 23/40 (58%) pts but paradoxically overestimated calcification in 12 of the 16 (75%) pts with calcified lesions. Conclusions: Presence of lesion calcium does not predict calcification elsewhere nor does its arc adequately quantify the extent of coronary calcification. Calcified luminal surface area is an improved IVUS method that accurately quantifies total arterial calcification.

AB - The current method of quantifying coronary calcium (CC) with intravascular ultrasound (IVUS) measures the arc of calcium from the 2-dimensional (2D) cross-sectional image at the lesion site. Unfortunately, the 2D method neglects calcification at other sites within the artery and may not adequately represent the degree of total CC. We therefore used a new method, which has previously been pathologically validated, to quantify CC as a percent of the luminal surface area and compared it to the current 2D method. IVUS was performed with a motorized pullback and 2D images were digitized every 1 mm. Total and calcified luminal circumference was measured and, using Simpson's method, the total luminal and calcified luminal surface area was calculated. Standard 2D analysis of calcium arc was performed independently. Results: Pre-interventional IVUS was performed in 41 arteries in 40 pts (33 males, 7 females; 58.3±10.2 years) for a total of 2348 cross-sectional images analyzed. Calcified target lesions were detected in 16/41 coronaries (39%) with an average arc of 79.7±12.0 degrees; 18 of the remaining 25 (72%) had calcium elsewhere. There was no relationship (p=ns) between arc of calcium and either absolute calcified luminal surface area (46.1±45.0 mm2) or relative calcified surface area (7.8±8.0%). 2D calcium quantification underestimated total CC content in 23/40 (58%) pts but paradoxically overestimated calcification in 12 of the 16 (75%) pts with calcified lesions. Conclusions: Presence of lesion calcium does not predict calcification elsewhere nor does its arc adequately quantify the extent of coronary calcification. Calcified luminal surface area is an improved IVUS method that accurately quantifies total arterial calcification.

UR - http://www.scopus.com/inward/record.url?scp=33748816642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748816642&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33748816642

VL - 10

SP - 406

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 4

ER -