Calcifying pseudoneoplasms of the neuraxis: CT, MR imaging, and histologic features

Ashley H. Aiken, H. Akgun, T. Tihan, N. Barbaro, C. Glastonbury

Research output: Contribution to journalArticle

60 Scopus citations


BACKGROUND AND PURPOSE: Non-neoplastic, calcified, fibro-osseous lesions known as "calcifying pseudoneoplasms of the neuraxis" (CAPNON) are rare and can occur anywhere within the neuraxis. The radiologic and histopathologic characteristics of this unusual entity are not well understood. We present the largest series reviewing the MR imaging features of CAPNON. MATERIALS AND METHODS: The MR and CT imaging features in 4 patients with a pathologic diagnosis of "calcifying pseudoneoplasms of the neuraxis" were retrospectively reviewed. A neuropathologist also analyzed the histopathologic features for typical and atypical patterns. RESULTS: Imaging features were strikingly similar for all 4 patients. All lesions appeared T1 and T2 hypointense without vasogenic edema. All tumors had dense calcification, and 3 tumors showed minimal linear internal or rim enhancement on MR imaging. CONCLUSIONS: CAPNON may mimic more common vascular malformations or neoplasms and are often not considered in the differential diagnosis of calcified lesions. CAPNON should be included in the differential diagnosis of a calcified mass with marked T1 and T2 hypointensity and limited to no enhancement. Careful CT and MR imaging evaluation can suggest this entity, and this preoperative recognition may help subsequent management decisions.

Original languageEnglish (US)
Pages (from-to)1256-1260
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number6
StatePublished - Jun 1 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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