Calciphylaxis and vascular calcification

A continuum of extra-skeletal osteogenesis

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a distinct entity, we believe it is but a single manifestation of a complicated systemic process that leads to vascular calcification in both the intimal and medial layers of all forms of arteries in patients with chronic kidney disease. The pathophysiology of vascular calcification includes injury leading to vascular smooth muscle cell de-differentiation to osteoblast-like cells, a nidus "formation" of matrix proteins with and without apoptotic bodies, initiation and extension of mineralization, and a balance of pro-calcification factors and inhibitory calcification factors. The clinical manifestations depend upon the location of the affected artery. The rationale behind this hypothesis is discussed in this review.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalPediatric Nephrology
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2003

Fingerprint

Calciphylaxis
Vascular Calcification
Osteogenesis
Arteries
Tunica Intima
Arterioles
Osteoblasts
Chronic Renal Insufficiency
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Differentiation
Necrosis
Skin
Wounds and Injuries
Proteins

Keywords

  • Calcific uremic arteriolopathy
  • Calciphylaxis
  • Chronic kidney disease
  • Core-binding factor α-1
  • Dialysis
  • Vascular calcification

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Calciphylaxis and vascular calcification : A continuum of extra-skeletal osteogenesis. / Moe, Sharon; Chen, Xuening (Neal).

In: Pediatric Nephrology, Vol. 18, No. 10, 01.10.2003, p. 969-975.

Research output: Contribution to journalArticle

@article{48efdac517a24c97ae477093256f24f4,
title = "Calciphylaxis and vascular calcification: A continuum of extra-skeletal osteogenesis",
abstract = "Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a distinct entity, we believe it is but a single manifestation of a complicated systemic process that leads to vascular calcification in both the intimal and medial layers of all forms of arteries in patients with chronic kidney disease. The pathophysiology of vascular calcification includes injury leading to vascular smooth muscle cell de-differentiation to osteoblast-like cells, a nidus {"}formation{"} of matrix proteins with and without apoptotic bodies, initiation and extension of mineralization, and a balance of pro-calcification factors and inhibitory calcification factors. The clinical manifestations depend upon the location of the affected artery. The rationale behind this hypothesis is discussed in this review.",
keywords = "Calcific uremic arteriolopathy, Calciphylaxis, Chronic kidney disease, Core-binding factor α-1, Dialysis, Vascular calcification",
author = "Sharon Moe and Chen, {Xuening (Neal)}",
year = "2003",
month = "10",
day = "1",
doi = "10.1007/s00467-003-1276-0",
language = "English",
volume = "18",
pages = "969--975",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - Calciphylaxis and vascular calcification

T2 - A continuum of extra-skeletal osteogenesis

AU - Moe, Sharon

AU - Chen, Xuening (Neal)

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a distinct entity, we believe it is but a single manifestation of a complicated systemic process that leads to vascular calcification in both the intimal and medial layers of all forms of arteries in patients with chronic kidney disease. The pathophysiology of vascular calcification includes injury leading to vascular smooth muscle cell de-differentiation to osteoblast-like cells, a nidus "formation" of matrix proteins with and without apoptotic bodies, initiation and extension of mineralization, and a balance of pro-calcification factors and inhibitory calcification factors. The clinical manifestations depend upon the location of the affected artery. The rationale behind this hypothesis is discussed in this review.

AB - Calciphylaxis, more appropriately termed calcific uremic arteriolopathy, is a clinical syndrome of skin necrosis due to medial calcification of the small arterioles. While this disease has been described as a distinct entity, we believe it is but a single manifestation of a complicated systemic process that leads to vascular calcification in both the intimal and medial layers of all forms of arteries in patients with chronic kidney disease. The pathophysiology of vascular calcification includes injury leading to vascular smooth muscle cell de-differentiation to osteoblast-like cells, a nidus "formation" of matrix proteins with and without apoptotic bodies, initiation and extension of mineralization, and a balance of pro-calcification factors and inhibitory calcification factors. The clinical manifestations depend upon the location of the affected artery. The rationale behind this hypothesis is discussed in this review.

KW - Calcific uremic arteriolopathy

KW - Calciphylaxis

KW - Chronic kidney disease

KW - Core-binding factor α-1

KW - Dialysis

KW - Vascular calcification

UR - http://www.scopus.com/inward/record.url?scp=0141920487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141920487&partnerID=8YFLogxK

U2 - 10.1007/s00467-003-1276-0

DO - 10.1007/s00467-003-1276-0

M3 - Article

VL - 18

SP - 969

EP - 975

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 10

ER -