Calcium and contractile responses of coronary arteries from aldosterone-salt hypertensive rats

agonistdependent dissociation in hypertension?

C. Y. Liu, M. Maltox, A. W. Jones, J. L. Parker, Michael Sturek

Research output: Contribution to journalArticle

Abstract

Recent studies showed that coronary reactivity exhibits agonist-selective alterations in hypertensive rats. This study examined contractile and Ca responses of coronary artery rings (COR) from normotensive control-salt rats (CSR) and aldosterone-salt hypertensive rats (AHR). Isometric tension was measured with a microvessel myograph. COR from AHR exhibited smaller contractions to KCI (80 mM), serotonin (5-HT, 10 uM) and prostaglandin F2a (PGF2a, 100 uM). Maximal contractions were 3.0±0.4mN/mm, 3.4±0.4 mN/mm and 3.8±0.6 mN/mm in CSR and 1.1±0.3mN/mm, 1.1±0.4mN/mm and 0-9 mN/mm in AHR (pm response to KCI was smaller in AHR than CSR (46±9 nM vs. 141±13 nM, pm responses to maximal concentration of 5-HT (10 μM) were similar between CSR and AHR (43±9 nM vs. 39±8 nM, n=18-21). Therefore, while the attenuated contractile response to depolarization is matched by a decreased Cam response, an agonist-dependent dissociation of Cam regulation and contraction appears to exist in coronary arteries of hypertensive rats. (SupportNIH grants RCDA HL02872, HL15852; AHA grant 93011900: and a postdoctoral fellowship from AHA Missouri-Affiliate).

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

aldosterone
coronary vessels
Aldosterone
hypertension
Rats
Coronary Vessels
Salts
Hypertension
Calcium
salts
calcium
rats
serotonin
Serotonin
Cams
Organized Financing
agonists
Rat control
Depolarization
Microvessels

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Calcium and contractile responses of coronary arteries from aldosterone-salt hypertensive rats : agonistdependent dissociation in hypertension? / Liu, C. Y.; Maltox, M.; Jones, A. W.; Parker, J. L.; Sturek, Michael.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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