Calcium and sodium channels in spontaneously contracting vascular muscle cells

Michael Sturek, Kent Hermsmeyer

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 μM) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalScience
Volume233
Issue number4762
DOIs
StatePublished - Jan 1 1986

Fingerprint

Sodium Channels
Calcium Channels
Muscle Cells
Blood Vessels
Tetrodotoxin
Cadmium
Barium
Calcium
Muscles

ASJC Scopus subject areas

  • General

Cite this

Calcium and sodium channels in spontaneously contracting vascular muscle cells. / Sturek, Michael; Hermsmeyer, Kent.

In: Science, Vol. 233, No. 4762, 01.01.1986, p. 475-478.

Research output: Contribution to journalArticle

Sturek, Michael ; Hermsmeyer, Kent. / Calcium and sodium channels in spontaneously contracting vascular muscle cells. In: Science. 1986 ; Vol. 233, No. 4762. pp. 475-478.
@article{88622d9e47334fdd9925c2b197062a3f,
title = "Calcium and sodium channels in spontaneously contracting vascular muscle cells",
abstract = "Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 μM) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.",
author = "Michael Sturek and Kent Hermsmeyer",
year = "1986",
month = "1",
day = "1",
doi = "10.1126/science.2425434",
language = "English (US)",
volume = "233",
pages = "475--478",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4762",

}

TY - JOUR

T1 - Calcium and sodium channels in spontaneously contracting vascular muscle cells

AU - Sturek, Michael

AU - Hermsmeyer, Kent

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 μM) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.

AB - Electrophysiological recordings of inward currents from whole cells showed that vascular muscle cells have one type of sodium channel and two types of calcium channels. One of the calcium channels, the transient calcium channel, was activated by small depolarizations but then rapidly inactivated. It was equally permeable to calcium and barium and was blocked by cadmium, but not by tetrodotoxin. The other type, the sustained calcium channel, was activated by larger depolarizations, but inactivated very little; it was more permeable to barium than calcium. The sustained calcium channel was more sensitive to block by cadmium than the transient channel, but also was not blocked by tetrodotoxin. The sodium channel inactivated 15 times more rapidly than the transient calcium channel and at more negative voltages. This sodium channel, which is unusual because it is only blocked by a very high (60 μM) tetrodotoxin concentration but not by cadmium, is the first to be characterized in vascular muscle, and together with the two calcium channels, provides a basis for different patterns of excitation in vascular muscles.

UR - http://www.scopus.com/inward/record.url?scp=0022531909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022531909&partnerID=8YFLogxK

U2 - 10.1126/science.2425434

DO - 10.1126/science.2425434

M3 - Article

C2 - 2425434

AN - SCOPUS:0022531909

VL - 233

SP - 475

EP - 478

JO - Science

JF - Science

SN - 0036-8075

IS - 4762

ER -