Calcium malabsorption in the elderly

The effect of treatment with oral 25-hydroxyvitamin D3

R. M. Francis, Munro Peacock, J. H. Storer, A. E. Davies, W. B. Brown, B. E. Nordin

Research output: Contribution to journalArticle

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Abstract

Calcium malabsorption is common in the elderly and may contribute to the development of age-related bone loss. To investigate its cause, the authors have measured radio-calcium absorption, plasma 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone in forty-eight elderly women with a normal plasma creatinine. Calcium malabsorption was associated with low 25-hydroxyvitamin D concentrations and was corrected by increasing these into the normal range by treatment with oral 25-hydroxyvitamin D3. Treatment also increased 1,25-dihydroxyvitamin D, and decreased parathyroid hormone concentrations. Before treatment, plasma parathyroid hormone was related to plasma creatinine but not to 25-hydroxyvitamin D, and the change in absorption on treatment correlated inversely with plasma creatinine. 51Cr EDTA clearance was measured in sixteen elderly women and confirmed that renal impairment was common even with a plasma creatinine in the normal range. The authors' results suggest that calcium malabsorption in the elderly is predominantly due to vitamin D deficiency; renal impairment is also common and contributes to the malabsorption by increasing the requirements for vitamin D.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalEuropean Journal of Clinical Investigation
Volume13
Issue number5
StatePublished - 1983
Externally publishedYes

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Calcifediol
Calcium
Plasmas
Creatinine
Parathyroid Hormone
Vitamin D
Reference Values
Therapeutics
Kidney
Vitamin D Deficiency
Radio
Edetic Acid
Osteoporosis
Bone
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Francis, R. M., Peacock, M., Storer, J. H., Davies, A. E., Brown, W. B., & Nordin, B. E. (1983). Calcium malabsorption in the elderly: The effect of treatment with oral 25-hydroxyvitamin D3. European Journal of Clinical Investigation, 13(5), 391-396.

Calcium malabsorption in the elderly : The effect of treatment with oral 25-hydroxyvitamin D3. / Francis, R. M.; Peacock, Munro; Storer, J. H.; Davies, A. E.; Brown, W. B.; Nordin, B. E.

In: European Journal of Clinical Investigation, Vol. 13, No. 5, 1983, p. 391-396.

Research output: Contribution to journalArticle

Francis, RM, Peacock, M, Storer, JH, Davies, AE, Brown, WB & Nordin, BE 1983, 'Calcium malabsorption in the elderly: The effect of treatment with oral 25-hydroxyvitamin D3', European Journal of Clinical Investigation, vol. 13, no. 5, pp. 391-396.
Francis, R. M. ; Peacock, Munro ; Storer, J. H. ; Davies, A. E. ; Brown, W. B. ; Nordin, B. E. / Calcium malabsorption in the elderly : The effect of treatment with oral 25-hydroxyvitamin D3. In: European Journal of Clinical Investigation. 1983 ; Vol. 13, No. 5. pp. 391-396.
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