Calcium metabolism in health and disease

Research output: Contribution to journalArticle

302 Citations (Scopus)

Abstract

This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD). Calcium balance refers to the state of the calcium body stores, primarily in bone, which are largely a function of dietary intake, intestinal absorption, renal excretion, and bone remodeling. Bone calcium balance can be positive, neutral, or negative, depending on a number of factors, including growth, aging, and acquired or inherited disorders. Calcium homeostasis refers to the hormonal regulation of serum ionized calcium by parathyroid hormone, 1,25-dihydroxyvitamin D, and serum ionized calcium itself, which together regulate calcium transport at the gut, kidney, and bone. Hypercalcemia and hypocalcemia indicate serious disruption of calcium homeostasis but do not reflect calcium balance on their own. Calcium balance studies have determined the dietary and supplemental calcium requirements needed to optimize bone mass in healthy subjects. However, similar studies are needed in CKD-MBD, which disrupts both calcium balance and homeostasis, because these data in healthy subjects may not be generalizable to this patient group. Importantly, increasing evidence suggests that calcium supplementation may enhance soft tissue calcification and cardiovascular disease in CKD-MBD. Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients.

Original languageEnglish
JournalClinical Journal of the American Society of Nephrology
Volume5
Issue numberSUPPL. 1
DOIs
StatePublished - 2010

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Calcium
Health
Chronic Kidney Disease-Mineral and Bone Disorder
Healthy Volunteers
Homeostasis
Bone and Bones
Dietary Calcium
Hypocalcemia
Bone Remodeling
Intestinal Absorption
Hypercalcemia
Parathyroid Hormone
Serum
Intercellular Signaling Peptides and Proteins
Cardiovascular Diseases
Kidney

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Calcium metabolism in health and disease. / Peacock, Munro.

In: Clinical Journal of the American Society of Nephrology, Vol. 5, No. SUPPL. 1, 2010.

Research output: Contribution to journalArticle

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