Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis?

A retrospective study of pathologic correlation

Julia Kim Leblanc, Jey Hsin Chen, Mohammad Al-Haddad, Leticia Luz, Lee McHenry, Stuart Sherman, Michelle Juan, John DeWitt

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate associations between endoscopic ultrasound (EUS) criteria for chronic pancreatitis (CP) and coexisting pancreatic intraepithelial neoplasia (PanIN) lesions. Methods: Patients with known or suspected CP who underwent pancreatic resection within a year of EUS were selected. Histology slides and EUS images were reviewed for evidence of pancreatic fibrosis. Results: Ninety-seven (51 men; mean age, 53 [12] years) underwent EUS within a 1 year or less of EUS. Pancreatic intraepithelial neoplasia lesions were found in 84 (87%) patients. Pancreatic intraepithelial neoplasia 1, 2, and 3 lesions were seen in 71 (83%), 10 (14%), and 1 (2%), respectively. Two patients had more than 1 PanIN grade (one had PanIN 1 and 2 and the other had PanIN 1 and 3). The mean number of EUS criteria for PanIN 1, 2, and 3 lesions were 3.9, 4.5, and 5.5, respectively. The odds ratio for the association between PanIN 2 and hyperechoic foci without shadowing in the pancreas head was 8.5 (P = 0.05). The odds ratio for the association between PanIN 2 and lobularity with honeycombing was 2.7 (P = ns). Advanced PanIN lesions had greater than or equal to 4 EUS criteria for CP. Conclusions: Pancreatic intraepithelial neoplasia lesions were highly prevalent in CP resections. Increasing PanIN grade is observed with increasing fibrosis score and increasing number of EUS criteria for CP.

Original languageEnglish
Pages (from-to)849-854
Number of pages6
JournalPancreas
Volume43
Issue number6
DOIs
StatePublished - 2014

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Chronic Pancreatitis
Retrospective Studies
Neoplasms
Fibrosis
Odds Ratio
Pancreas
Histology

Keywords

  • chronic pancreatitis
  • endoscopic ultrasound (EUS)
  • histology
  • pancreatic intraepithelial neoplasia (PanIN)
  • pathology

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Can endoscopic ultrasound predict pancreatic intraepithelial neoplasia lesions in chronic pancreatitis? A retrospective study of pathologic correlation. / Leblanc, Julia Kim; Chen, Jey Hsin; Al-Haddad, Mohammad; Luz, Leticia; McHenry, Lee; Sherman, Stuart; Juan, Michelle; DeWitt, John.

In: Pancreas, Vol. 43, No. 6, 2014, p. 849-854.

Research output: Contribution to journalArticle

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N2 - Objective: This study aimed to evaluate associations between endoscopic ultrasound (EUS) criteria for chronic pancreatitis (CP) and coexisting pancreatic intraepithelial neoplasia (PanIN) lesions. Methods: Patients with known or suspected CP who underwent pancreatic resection within a year of EUS were selected. Histology slides and EUS images were reviewed for evidence of pancreatic fibrosis. Results: Ninety-seven (51 men; mean age, 53 [12] years) underwent EUS within a 1 year or less of EUS. Pancreatic intraepithelial neoplasia lesions were found in 84 (87%) patients. Pancreatic intraepithelial neoplasia 1, 2, and 3 lesions were seen in 71 (83%), 10 (14%), and 1 (2%), respectively. Two patients had more than 1 PanIN grade (one had PanIN 1 and 2 and the other had PanIN 1 and 3). The mean number of EUS criteria for PanIN 1, 2, and 3 lesions were 3.9, 4.5, and 5.5, respectively. The odds ratio for the association between PanIN 2 and hyperechoic foci without shadowing in the pancreas head was 8.5 (P = 0.05). The odds ratio for the association between PanIN 2 and lobularity with honeycombing was 2.7 (P = ns). Advanced PanIN lesions had greater than or equal to 4 EUS criteria for CP. Conclusions: Pancreatic intraepithelial neoplasia lesions were highly prevalent in CP resections. Increasing PanIN grade is observed with increasing fibrosis score and increasing number of EUS criteria for CP.

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