Can We Detect Chronic Pancreatitis with Low Serum Pancreatic Enzyme Levels?

Chang Il Kwon, Hong Joo Kim, Paul Korc, Eun Kwang Choi, Gail M. McNulty, Jeffrey J. Easler, Ihab I. El Hajj, James Watkins, Evan Fogel, Lee McHenry, Michelle Zimmerman, Stuart Sherman, Glen Lehman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objectives The aims of this study were to evaluate whether serum pancreatic enzyme levels could be used to aid screening for chronic pancreatitis (CP). Methods 170 healthy volunteers were screened and prospectively enrolled in the control group. 150 patients who were diagnosed with calcific CP were enrolled in the patient group by retrospective review. Serum amylase and lipase levels were compared between the 2 groups. Results The mean values ± SD of the control group were compared with those of the patient group for serum amylase level (48.1 ± 13.2 vs 34.8 ± 17.2 U/L, P < 0.001) and serum lipase level (26.4 ± 11.3 vs 16.3 ± 11.2 U/L, P < 0.001). On the receiver operating characteristic curve analysis for amylase level, area under the curve was 0.740 (95% confidence interval), and sensitivity and specificity were 38.7% and 94.1%, respectively, with a cutoff value of 27.5 U/L. On the receiver operating characteristic curve analysis for lipase level, area under the curve was 0.748 (95% confidence interval), and sensitivity and specificity were 33.3% and 95.9%, respectively, with a cutoff value of 10.5 U/L. Conclusions Our results suggest that low serum pancreatic enzyme levels can be used to aid in detection of CP.

Original languageEnglish (US)
Pages (from-to)1184-1188
Number of pages5
JournalPancreas
Volume45
Issue number8
DOIs
StatePublished - Sep 1 2016

Keywords

  • amylase
  • chronic
  • diagnosis
  • lipase
  • pancreatitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Kwon, C. I., Kim, H. J., Korc, P., Choi, E. K., McNulty, G. M., Easler, J. J., El Hajj, I. I., Watkins, J., Fogel, E., McHenry, L., Zimmerman, M., Sherman, S., & Lehman, G. (2016). Can We Detect Chronic Pancreatitis with Low Serum Pancreatic Enzyme Levels? Pancreas, 45(8), 1184-1188. https://doi.org/10.1097/MPA.0000000000000612