Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism

Kathleen K. Bucholz, Andrew C. Heath, Theodore Reich, Victor M. Hesselbrock, John R. Kramer, John I. Nurnberger, Marc A. Schuckit

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

We attempted to identify distinctive subtypes of alcoholics using latent class analysis with data from 2551 relatives of alcoholic probands, all participants in the Collaborative Study of the Genetics of Alcoholism. Latent class analysis is a multivariate technique using cross-classified data to identify unobserved ('latent') classes that explain the relationships among observed variables. Data on 37 lifetime symptoms of alcohol dependence from 1360 female and 1191 male relatives were analyzed, with a 4 class solution selected as the best rifling among the 2 through 8 class solutions that were examined. We observed the following classes: class 1, nonproblem drinkers (39.6% male, 50% female); class 2, mild alcoholics (persistent desire to stop, tolerance, and blackouts) (31.8% male, 28.7% female); class 3, moderate alcoholics (social, health, and emotional problems) (18.9% male, 14.6% female); and class 4, severely affected alcoholics (withdrawal, inability to stop drinking, craving, health, and emotional problems) (9.7% male, 6.7% female). There was little evidence for the construct of alcohol abuse; endorsement probabilities for abuse symptoms (e.g., arrests and DWIs) were very low for all classes, whereas hazardous use was common among men in class 1. In addition to those in class 3 and class 4, a majority of men in class 2 qualified for DSM-III-R alcohol dependence, suggesting a bimodal distribution of drinkers and alcoholics, with little nondependent problem drinking among men in this high-risk sample. We conclude that, in this sample, alcoholism is not differentiated by symptom profiles but rather lies on a continuum of severity, with the possible exception of withdrawal, which characterized only class 4 individuals.

Original languageEnglish (US)
Pages (from-to)1462-1471
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume20
Issue number8
DOIs
StatePublished - Jan 1 1996

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Alcoholics
Alcoholism
Multicenter Studies
Alcohols
Health
Drinking
Diagnostic and Statistical Manual of Mental Disorders

Keywords

  • Alcoholism
  • Family Studies
  • Latent Class Analysis
  • Subtyping

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. / Bucholz, Kathleen K.; Heath, Andrew C.; Reich, Theodore; Hesselbrock, Victor M.; Kramer, John R.; Nurnberger, John I.; Schuckit, Marc A.

In: Alcoholism: Clinical and Experimental Research, Vol. 20, No. 8, 01.01.1996, p. 1462-1471.

Research output: Contribution to journalArticle

Bucholz, Kathleen K. ; Heath, Andrew C. ; Reich, Theodore ; Hesselbrock, Victor M. ; Kramer, John R. ; Nurnberger, John I. ; Schuckit, Marc A. / Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. In: Alcoholism: Clinical and Experimental Research. 1996 ; Vol. 20, No. 8. pp. 1462-1471.
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