Canals of Hearing

Recent Insights and Current Knowledge

Romil Saxena, Neil Theise

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The canals of Hering (CoH) begin in the lobules, are lined partially by cholangiocytes and partly by hepatocytes, and conduct bile from bile canaliculi to terminal bile ducts in portal tracts. They are not readily apparent on routine histological staining but are highlighted by the biliary cytokeratins CK19 and CK7. There is on average 1 CoH per 10 μm of bile duct length. The canals represent the true hepatocytic-biliary interface that thus lies within the lobule and not at the limiting plate. The CoH are destroyed early in primary biliary cirrhosis, perhaps explaining lobular "hepatitis" in this disease. They may also be the primary sites of scarring in methotrexate toxicity. Most intriguingly, the CoH have been speculated to harbor intraorgan stem cells of the liver, perhaps forming the hepatic stem cell "niche" and have been demonstrated to proliferate in disease states.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalSeminars in Liver Disease
Volume24
Issue number1
DOIs
StatePublished - Feb 2004

Fingerprint

Bile Ducts
Hearing
Hepatocytes
Bile Canaliculi
Stem Cell Niche
Biliary Liver Cirrhosis
Keratins
Methotrexate
Bile
Hepatitis
Cicatrix
Stem Cells
Staining and Labeling
Liver

Keywords

  • Canals of Hering
  • Methotrexate
  • Primary biliary cirrhosis
  • Stem cells

ASJC Scopus subject areas

  • Hepatology

Cite this

Canals of Hearing : Recent Insights and Current Knowledge. / Saxena, Romil; Theise, Neil.

In: Seminars in Liver Disease, Vol. 24, No. 1, 02.2004, p. 43-48.

Research output: Contribution to journalArticle

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