Cancer and leukemia group B pathology committee guidelines for tissue microarray construction representing multicenter prospective clinical trial tissues

David L. Rimm, Torsten O. Nielsen, Scott D. Jewell, Daniel C. Rohrer, Gloria Broadwater, Frederic Waldman, Kisha A. Mitchell, Baljit Singh, Gregory J. Tsongalis, Wendy L. Frankel, Anthony M. Magliocco, Jonathan F. Lara, Eric D. Hsi, Ira J. Bleiweiss, Sunil S. Badve, Beiyun Chen, Peter M. Ravdin, Richard L. Schilsky, Ann Thor, Donald A. Berry

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Practice-changing evidence requires confirmation, preferably in multi-institutional clinical trials. The collection of tissue within such trials has enabled biomarker studies and evaluation of companion diagnostic tests. Tissue microarrays (TMAs) have become a standard approach in many cooperative oncology groups. A principal goal is to maximize the number of assays with this precious tissue. However, production strategies for these arrays have not been standardized, possibly decreasing the value of the study. In this article, members of the Cancer and Leukemia Group B Pathology Committee relay our experiences as array facility directors and propose guidelines regarding the production of high-quality TMAs for cooperative group studies. We also discuss statistical issues arising from having a proportion of patients available for TMAs and the possibility that patients with TMAs fail to represent the greater study population.

Original languageEnglish (US)
Pages (from-to)2282-2290
Number of pages9
JournalJournal of Clinical Oncology
Volume29
Issue number16
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Rimm, D. L., Nielsen, T. O., Jewell, S. D., Rohrer, D. C., Broadwater, G., Waldman, F., Mitchell, K. A., Singh, B., Tsongalis, G. J., Frankel, W. L., Magliocco, A. M., Lara, J. F., Hsi, E. D., Bleiweiss, I. J., Badve, S. S., Chen, B., Ravdin, P. M., Schilsky, R. L., Thor, A., & Berry, D. A. (2011). Cancer and leukemia group B pathology committee guidelines for tissue microarray construction representing multicenter prospective clinical trial tissues. Journal of Clinical Oncology, 29(16), 2282-2290. https://doi.org/10.1200/JCO.2010.33.2023