Cancer associated fibroblasts: Naughty neighbors that drive ovarian cancer progression

Subramanyam Dasari, Yiming Fang, Anirban Mitra

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not improved significantly over the last several decades. In order to improve therapeutic approaches and patient outcomes, there is a critical need for focused research towards better understanding of the disease. Recent findings have revealed that the tumor microenvironment plays an essential role in promoting cancer progression and metastasis. The tumor microenvironment consists of cancer cells and several different types of normal cells recruited and reprogrammed by the cancer cells to produce factors beneficial to tumor growth and spread. These normal cells present within the tumor, along with the various extracellular matrix proteins and secreted factors, constitute the tumor stroma and can compose 10–60% of the tumor volume. Cancer associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment, and play a critical role in promoting many aspects of tumor function. This review will describe the various hypotheses about the origin of CAFs, their major functions in the tumor microenvironment in ovarian cancer, and will discuss the potential of targeting CAFs as a possible therapeutic approach.

Original languageEnglish (US)
Article number406
JournalCancers
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Ovarian Neoplasms
Tumor Microenvironment
Neoplasms
Cancer-Associated Fibroblasts
Extracellular Matrix Proteins
Tumor Burden
Neoplasm Metastasis
Therapeutics
Growth
Research

Keywords

  • Angiogenesis
  • Cancer associated fibroblasts
  • Chemoresistance
  • Cross-talk
  • ECM
  • Fibroblast
  • Invasion
  • Ovarian cancer
  • Therapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cancer associated fibroblasts : Naughty neighbors that drive ovarian cancer progression. / Dasari, Subramanyam; Fang, Yiming; Mitra, Anirban.

In: Cancers, Vol. 10, No. 11, 406, 01.11.2018.

Research output: Contribution to journalReview article

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