Cancer exosomes for early pancreatic cancer diagnosis and role in metastasis

Murray Korc, Samantha Deitz McElyea

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a treatment-recalcitrant and highly metastatic cancer. Recent studies have demonstrated that PDAC is associated with an increased release of small vesicles called exosomes that are ~40 to 130 nanometers in diameter. These exosomes may derive from pancreatic cancer cells, cancer-associated fibroblasts, and infiltrating immune and inflammatory cells. They carry a cargo rich in proteins, lipids, DNA, and microRNAs. Exosomes can modulate the tumor microenvironment, promote pancreatic cancer cell proliferation, invasion, and metastasis, and prime the pre-metastatic niche to facilitate formation of distant metastatic lesions. Components of the exosomal cargo may also serve as diagnostic biomarkers and guide the design of precision medicine strategies. Finally, exosomes have been proposed to act as biological nanoparticles that can be loaded with drugs for therapeutic use.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer
PublisherSpringer New York
Pages1361-1377
Number of pages17
ISBN (Electronic)9781493971930
ISBN (Print)9781493971916
DOIs
StatePublished - Apr 11 2018

Keywords

  • Early diagnosis
  • Exosomes
  • Metastasis
  • MicroRNAs

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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  • Cite this

    Korc, M., & McElyea, S. D. (2018). Cancer exosomes for early pancreatic cancer diagnosis and role in metastasis. In Pancreatic Cancer (pp. 1361-1377). Springer New York. https://doi.org/10.1007/978-1-4939-7193-0_67