Cancer history: A predictor of IPMN subtype and dysplastic status?

Rosalie A. Carr, Brandon A. Kiel, Alexandra M. Roch, Eugene P. Ceppa, Michael G. House, Nicholas J. Zyromski, Attila Nakeeb, C. Max Schmidt

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to determine the association of PMH and FH of pancreatic (PDAC) and non-pancreatic cancers with IPMN malignant risk. Methods: A retrospective review of a prospective database of IPMN patients undergoing resection was performed to assess FH and PMH. Results: FH of PDAC was present in 13% of 362 included patients. Of these, 8% had at least one first degree relative (FDR) with PDAC. The rate of PDAC positive FH in non-invasive versus invasive IPMN patients was 14% and 8%, respectively (p = 0.3). In main duct IPMN patients, FH (44%) and PMH of non-pancreatic cancer (16%) was higher than that seen in branch duct IPMN (FH 29%; PMH 6%; p = 0.004 and 0.008). Conclusions: FH of PDAC is not associated with IPMN malignant progression. FH and PMH of non-pancreatic cancer is associated with main duct IPMN, the subtype with the highest rate of invasive transformation.

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalAmerican Journal of Surgery
Volume215
Issue number3
DOIs
StatePublished - Mar 2018

Keywords

  • Family history
  • IPMN
  • Malignant progression
  • Pancreatic ductal adenocarcinoma
  • Past medical history

ASJC Scopus subject areas

  • Surgery

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