Cancer-related fatigue and its associations with depression and anxiety: A systematic review

Linda F. Brown, Kurt Kroenke

Research output: Contribution to journalReview article

182 Scopus citations

Abstract

Background: Fatigue is an important symptom in cancer and has been shown to be associated with psychological distress. Objective: This review assesses evidence regarding associations of cancer-related fatigue with depression and anxiety. Method: Database searches yielded 59 studies reporting correlation coefficients or odds ratios. Results: The combined sample size was 12,103. Almost all studies showed a correlation of fatigue with depression and with anxiety. However, 31 different instruments were used to assess fatigue, suggesting a lack of consensus on measurement. Conclusion: This review confirms the association of fatigue with depression and anxiety. Directionality needs to be better delineated in longitudinal studies.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalPsychosomatics
Volume50
Issue number5
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

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