Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer

Y. Wang, F. Fang, S. Condello, Daniela Matei, Kenneth Nephew

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epithelial ovarian cancer (OC) is highly responsive to chemotherapy but most patients eventually relapse and develop chemoresistance and die from their disease. Reoccurrence of ovarian tumors has been attributed to persistence of dormant cells with stem cell characteristics, which has been defined as cancer stem cells (CSCs). This chapter will summarize current knowledge on CSCs in OC, including their putative origin, characteristics, and methods of isolation and targeting strategies. CSCs display specific genetic and epigenetic mechanisms that fuel their survival, self-renewal, and tumor-initiating capacity. Therapies targeting the epigenome show potential for eradicating CSCs by inducing their differentiation. A continued need to identify strategies that block stem cell-specific vulnerabilities remains with the goal of completely eradicating CSCs and prevent disease relapse.

Original languageEnglish (US)
Title of host publicationCancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance
PublisherElsevier Inc.
Pages231-259
Number of pages29
ISBN (Electronic)9780128039342
ISBN (Print)9780128038925
DOIs
StatePublished - Sep 1 2016

Fingerprint

Neoplastic Stem Cells
Stem cells
Ovarian Neoplasms
Stem Cells
Therapeutics
Recurrence
Tumors
Epigenomics
Chemotherapy
Neoplasms
Drug Therapy
Survival

Keywords

  • Cancer stem cells
  • DNA methylation
  • Epigenetics
  • Ovarian cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, Y., Fang, F., Condello, S., Matei, D., & Nephew, K. (2016). Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. In Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance (pp. 231-259). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803892-5.00009-7

Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. / Wang, Y.; Fang, F.; Condello, S.; Matei, Daniela; Nephew, Kenneth.

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. Elsevier Inc., 2016. p. 231-259.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wang, Y, Fang, F, Condello, S, Matei, D & Nephew, K 2016, Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. in Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. Elsevier Inc., pp. 231-259. https://doi.org/10.1016/B978-0-12-803892-5.00009-7
Wang Y, Fang F, Condello S, Matei D, Nephew K. Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. In Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. Elsevier Inc. 2016. p. 231-259 https://doi.org/10.1016/B978-0-12-803892-5.00009-7
Wang, Y. ; Fang, F. ; Condello, S. ; Matei, Daniela ; Nephew, Kenneth. / Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. Elsevier Inc., 2016. pp. 231-259
@inbook{da14d5c617e740d191b6196d7325712c,
title = "Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer",
abstract = "Epithelial ovarian cancer (OC) is highly responsive to chemotherapy but most patients eventually relapse and develop chemoresistance and die from their disease. Reoccurrence of ovarian tumors has been attributed to persistence of dormant cells with stem cell characteristics, which has been defined as cancer stem cells (CSCs). This chapter will summarize current knowledge on CSCs in OC, including their putative origin, characteristics, and methods of isolation and targeting strategies. CSCs display specific genetic and epigenetic mechanisms that fuel their survival, self-renewal, and tumor-initiating capacity. Therapies targeting the epigenome show potential for eradicating CSCs by inducing their differentiation. A continued need to identify strategies that block stem cell-specific vulnerabilities remains with the goal of completely eradicating CSCs and prevent disease relapse.",
keywords = "Cancer stem cells, DNA methylation, Epigenetics, Ovarian cancer",
author = "Y. Wang and F. Fang and S. Condello and Daniela Matei and Kenneth Nephew",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/B978-0-12-803892-5.00009-7",
language = "English (US)",
isbn = "9780128038925",
pages = "231--259",
booktitle = "Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer

AU - Wang, Y.

AU - Fang, F.

AU - Condello, S.

AU - Matei, Daniela

AU - Nephew, Kenneth

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Epithelial ovarian cancer (OC) is highly responsive to chemotherapy but most patients eventually relapse and develop chemoresistance and die from their disease. Reoccurrence of ovarian tumors has been attributed to persistence of dormant cells with stem cell characteristics, which has been defined as cancer stem cells (CSCs). This chapter will summarize current knowledge on CSCs in OC, including their putative origin, characteristics, and methods of isolation and targeting strategies. CSCs display specific genetic and epigenetic mechanisms that fuel their survival, self-renewal, and tumor-initiating capacity. Therapies targeting the epigenome show potential for eradicating CSCs by inducing their differentiation. A continued need to identify strategies that block stem cell-specific vulnerabilities remains with the goal of completely eradicating CSCs and prevent disease relapse.

AB - Epithelial ovarian cancer (OC) is highly responsive to chemotherapy but most patients eventually relapse and develop chemoresistance and die from their disease. Reoccurrence of ovarian tumors has been attributed to persistence of dormant cells with stem cell characteristics, which has been defined as cancer stem cells (CSCs). This chapter will summarize current knowledge on CSCs in OC, including their putative origin, characteristics, and methods of isolation and targeting strategies. CSCs display specific genetic and epigenetic mechanisms that fuel their survival, self-renewal, and tumor-initiating capacity. Therapies targeting the epigenome show potential for eradicating CSCs by inducing their differentiation. A continued need to identify strategies that block stem cell-specific vulnerabilities remains with the goal of completely eradicating CSCs and prevent disease relapse.

KW - Cancer stem cells

KW - DNA methylation

KW - Epigenetics

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=85017543679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017543679&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-803892-5.00009-7

DO - 10.1016/B978-0-12-803892-5.00009-7

M3 - Chapter

AN - SCOPUS:85017543679

SN - 9780128038925

SP - 231

EP - 259

BT - Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

PB - Elsevier Inc.

ER -