Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer

Y. Wang, F. Fang, S. Condello, D. Matei, K. P. Nephew

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epithelial ovarian cancer (OC) is highly responsive to chemotherapy but most patients eventually relapse and develop chemoresistance and die from their disease. Reoccurrence of ovarian tumors has been attributed to persistence of dormant cells with stem cell characteristics, which has been defined as cancer stem cells (CSCs). This chapter will summarize current knowledge on CSCs in OC, including their putative origin, characteristics, and methods of isolation and targeting strategies. CSCs display specific genetic and epigenetic mechanisms that fuel their survival, self-renewal, and tumor-initiating capacity. Therapies targeting the epigenome show potential for eradicating CSCs by inducing their differentiation. A continued need to identify strategies that block stem cell-specific vulnerabilities remains with the goal of completely eradicating CSCs and prevent disease relapse.

Original languageEnglish (US)
Title of host publicationCancer Stem Cells
Subtitle of host publicationTargeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance
PublisherElsevier Inc.
Pages231-259
Number of pages29
ISBN (Electronic)9780128039342
ISBN (Print)9780128038925
DOIs
StatePublished - Sep 1 2016

Keywords

  • Cancer stem cells
  • DNA methylation
  • Epigenetics
  • Ovarian cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wang, Y., Fang, F., Condello, S., Matei, D., & Nephew, K. P. (2016). Cancer Stem Cells as New Therapeutic Targets for Ovarian Cancer. In Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance (pp. 231-259). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803892-5.00009-7