Cancer to bone: A fatal attraction

Katherine N. Weilbaecher, Theresa Guise, Laurie K. McCauley

Research output: Contribution to journalArticle

567 Citations (Scopus)

Abstract

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumourĝ€"bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.

Original languageEnglish
Pages (from-to)411-425
Number of pages15
JournalNature Reviews Cancer
Volume11
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Bone Neoplasms
Bone and Bones
Neoplasms
Neoplasm Metastasis
Bone Matrix
Tumor Microenvironment
Bone Remodeling
Pain
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Weilbaecher, K. N., Guise, T., & McCauley, L. K. (2011). Cancer to bone: A fatal attraction. Nature Reviews Cancer, 11(6), 411-425. https://doi.org/10.1038/nrc3055

Cancer to bone : A fatal attraction. / Weilbaecher, Katherine N.; Guise, Theresa; McCauley, Laurie K.

In: Nature Reviews Cancer, Vol. 11, No. 6, 06.2011, p. 411-425.

Research output: Contribution to journalArticle

Weilbaecher, KN, Guise, T & McCauley, LK 2011, 'Cancer to bone: A fatal attraction', Nature Reviews Cancer, vol. 11, no. 6, pp. 411-425. https://doi.org/10.1038/nrc3055
Weilbaecher, Katherine N. ; Guise, Theresa ; McCauley, Laurie K. / Cancer to bone : A fatal attraction. In: Nature Reviews Cancer. 2011 ; Vol. 11, No. 6. pp. 411-425.
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