Cancer to bone: A fatal attraction

Katherine N. Weilbaecher, Theresa A. Guise, Laurie K. McCauley

Research output: Contribution to journalReview article

624 Scopus citations

Abstract

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the bone microenvironment to enhance tumour growth and to promote bone invasion. Understanding the crucial components of the bone microenvironment that influence tumour localization, along with the tumour-derived factors that modulate cellular and protein matrix components of bone to favour tumour expansion and invasion, is central to the pathophysiology of bone metastases. Basic findings of tumourĝ€"bone interactions have uncovered numerous therapeutic opportunities that focus on the bone microenvironment to prevent and treat bone metastases.

Original languageEnglish (US)
Pages (from-to)411-425
Number of pages15
JournalNature Reviews Cancer
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Weilbaecher, K. N., Guise, T. A., & McCauley, L. K. (2011). Cancer to bone: A fatal attraction. Nature Reviews Cancer, 11(6), 411-425. https://doi.org/10.1038/nrc3055