Candidate mechanisms for chemotherapy-induced cognitive changes

Tim A. Ahles, Andrew J. Saykin

Research output: Contribution to journalReview article

555 Scopus citations

Abstract

The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function.

Original languageEnglish (US)
Pages (from-to)192-201
Number of pages10
JournalNature Reviews Cancer
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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