Candidate mechanisms for chemotherapy-induced cognitive changes

Tim A. Ahles, Andrew Saykin

Research output: Contribution to journalArticle

521 Citations (Scopus)

Abstract

The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function.

Original languageEnglish
Pages (from-to)192-201
Number of pages10
JournalNature Reviews Cancer
Volume7
Issue number3
DOIs
StatePublished - Mar 2007

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Drug Therapy
DNA Repair
Cognition
Neurotransmitter Agents
Testosterone
Estrogens
Antioxidants
Neoplasms
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Cancer Research

Cite this

Candidate mechanisms for chemotherapy-induced cognitive changes. / Ahles, Tim A.; Saykin, Andrew.

In: Nature Reviews Cancer, Vol. 7, No. 3, 03.2007, p. 192-201.

Research output: Contribution to journalArticle

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