Canine Ileal Motor Activity after a Model of Jejunoileal Autotransplantation

Toshiyuki Tanaka, Nicholas Zyromski, Karen D. Libsch, Michael L. Kendrick, Michael G. Sarr

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To determine mechanisms by which extrinsic innervation to the jejunoileum controls ileal motility. Summary Background Data: Small bowel transplantation is complicated by diarrhea and delayed gastric emptying, possibly secondary to altered motility. Ileal motility after small bowel transplantation is poorly characterized. Methods: Motor activity was recorded from four dogs during fasting and after feeding small (64 Kcal) or large (256 Kcal) meals. Short-chain fatty acids known to induce unique ileal motor patterns were administered into the distal ileum during fasting. Dogs were studied before and after jejunoileal denervation simulating autotransplantation. Results: After jejunoileal denervation, the ileal migrating motor complex (MMC) persisted but was no longer temporally coordinated with duodenal MMCs. Spontaneous giant migrating contractions occurred more frequently after denervation and more commonly originated proximally in the jejunum, but the velocity of migration did not differ. In contrast, the incidence and characteristics of spontaneous discrete clustered contractions (DCCs) did not differ. Short-chain fatty acids reproducibly initiated giant migrating contractions and discrete clustered contractions in the distal ileum without differences before and after denervation. Large but not small meals inhibited the ileal MMC after denervation. Conclusions: Extrinsic innervation and/or intrinsic neural continuity with the duodenum and/or colon control temporal coordination of ileal motility with the duodenum and modulate postprandial inhibition of fasting motility and presence of giant migrating contractions. These changes in motility patterns may prove important in mediating enteric dysfunction after small bowel transplantation.

Original languageEnglish (US)
Pages (from-to)192-200
Number of pages9
JournalAnnals of Surgery
Volume237
Issue number2
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Autologous Transplantation
Denervation
Canidae
Motor Activity
Migrating Myoelectric Complexes
Fasting
Volatile Fatty Acids
Transplantation
Ileum
Duodenum
Meals
Dogs
Gastric Emptying
Jejunum
Diarrhea
Colon
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Canine Ileal Motor Activity after a Model of Jejunoileal Autotransplantation. / Tanaka, Toshiyuki; Zyromski, Nicholas; Libsch, Karen D.; Kendrick, Michael L.; Sarr, Michael G.

In: Annals of Surgery, Vol. 237, No. 2, 01.01.2003, p. 192-200.

Research output: Contribution to journalArticle

Tanaka, Toshiyuki ; Zyromski, Nicholas ; Libsch, Karen D. ; Kendrick, Michael L. ; Sarr, Michael G. / Canine Ileal Motor Activity after a Model of Jejunoileal Autotransplantation. In: Annals of Surgery. 2003 ; Vol. 237, No. 2. pp. 192-200.
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