Canonical and variant histones of protozoan parasites

Maria Carolina Dalmasso, William Sullivan, Sergio Oscar Angel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Protozoan parasites have tremendously diverse lifestyles that require adaptation to a remarkable assortment of different environmental conditions. In order to complete their life cycles, protozoan parasites rely on fine-tuning gene expression. In general, protozoa use novel regulatory elements, transcription factors, and epigenetic mechanisms to regulate their transcriptomes. One of the most surprising findings includes the nature of their histones - these primitive eukaryotes lack some histones yet harbor novel histone variants of unknown function. In this review, we describe the histone components of different protozoan parasites based on literature and database searching. We summarize the key discoveries regarding histones and histone variants and their impact on chromatin regulation in protozoan parasites. In addition, we list histone genes IDs, sequences, and genomic localization of several protozoan parasites and Microsporidia histones, obtained from a thorough search of genome databases. We then compare these findings with those observed in higher eukaryotes, allowing us to highlight some novel aspects of epigenetic regulation in protists and to propose questions to be addressed in the upcoming years.

Original languageEnglish
Pages (from-to)2086-2105
Number of pages20
JournalFrontiers in Bioscience
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Histones
Parasites
Eukaryota
Epigenomics
Genes
Databases
Protozoa
Microsporidia
Ports and harbors
Life Cycle Stages
Transcriptome
Gene expression
Chromatin
Life Style
Life cycle
Transcription Factors
Tuning
Genome
Gene Expression

Keywords

  • Epigenetic
  • Gene expression
  • Histone variant
  • Nucleosome
  • Protist parasites
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Canonical and variant histones of protozoan parasites. / Dalmasso, Maria Carolina; Sullivan, William; Angel, Sergio Oscar.

In: Frontiers in Bioscience, Vol. 16, No. 6, 01.06.2011, p. 2086-2105.

Research output: Contribution to journalArticle

Dalmasso, Maria Carolina ; Sullivan, William ; Angel, Sergio Oscar. / Canonical and variant histones of protozoan parasites. In: Frontiers in Bioscience. 2011 ; Vol. 16, No. 6. pp. 2086-2105.
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