Capillary perfusion patterns in single alveolar walls

O. Okada, Robert Presson, K. R. Kirk, P. S. Godbey, R. L. Capen, W. W. Wagner

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We studied capillary perfusion patterns in single alveolar walls through a transparent thoracic window implanted in pentobarbital-anesthetized dogs. The capillaries were maximally opened by brief inflation of a balloon in the left atrium to raise pressure. After the balloon was deflated and pulmonary hemodynamics returned to zone 2 baseline conditions, the capillaries that remained perfused in the observed field were videotaped with the use of in vivo microscopy. The cycle of elevated pressure and baseline observation was repeated three times. Perfusion of different capillaries during each of the observations would imply that the capillaries had characteristics that permitted flow to switch between segments. Perfusion of a specific set of pathways through the network each time would demonstrate that flowing blood sought a unique and repeatable combination of segments, presumably with the least total pathway resistance. We found that the same capillary segments were perfused 79% of the time, a strong indication that a reproducible combination of individual segmental resistances determined the predominant pattern of pulmonary capillary perfusion.

Original languageEnglish
Pages (from-to)1838-1844
Number of pages7
JournalJournal of Applied Physiology
Volume72
Issue number5
StatePublished - 1992

Fingerprint

Perfusion
Pressure
Lung
Economic Inflation
Pentobarbital
Heart Atria
Thorax
Hemodynamics
Observation
Dogs

Keywords

  • capillary recruitment
  • capillary resistances
  • dogs
  • pulmonary capillaries

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Okada, O., Presson, R., Kirk, K. R., Godbey, P. S., Capen, R. L., & Wagner, W. W. (1992). Capillary perfusion patterns in single alveolar walls. Journal of Applied Physiology, 72(5), 1838-1844.

Capillary perfusion patterns in single alveolar walls. / Okada, O.; Presson, Robert; Kirk, K. R.; Godbey, P. S.; Capen, R. L.; Wagner, W. W.

In: Journal of Applied Physiology, Vol. 72, No. 5, 1992, p. 1838-1844.

Research output: Contribution to journalArticle

Okada, O, Presson, R, Kirk, KR, Godbey, PS, Capen, RL & Wagner, WW 1992, 'Capillary perfusion patterns in single alveolar walls', Journal of Applied Physiology, vol. 72, no. 5, pp. 1838-1844.
Okada O, Presson R, Kirk KR, Godbey PS, Capen RL, Wagner WW. Capillary perfusion patterns in single alveolar walls. Journal of Applied Physiology. 1992;72(5):1838-1844.
Okada, O. ; Presson, Robert ; Kirk, K. R. ; Godbey, P. S. ; Capen, R. L. ; Wagner, W. W. / Capillary perfusion patterns in single alveolar walls. In: Journal of Applied Physiology. 1992 ; Vol. 72, No. 5. pp. 1838-1844.
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