Captivating capture: How microtubules attach to kinetochores

Sue Biggins, Claire E. Walczak

Research output: Contribution to journalReview article

88 Scopus citations

Abstract

Accurate chromosome segregation is essential to ensure genomic stability because the aneuploidy that results from segregation errors leads to birth defects and contributes to the development of cancer. Chromosome segregation is directed by the kinetochore, the chromosomal site of attachment to dynamic polymers called microtubules (MTs). Although the fidelity of chromosome segregation depends on precise interactions between kinetochores and MTs, it is still unclear how this interaction is mediated and regulated. Here we discuss current progress in determining how kinetochores assemble and attach to MTs during mitosis as well as how they correct errors.

Original languageEnglish (US)
Pages (from-to)R449-R460
JournalCurrent Biology
Volume13
Issue number11
DOIs
StatePublished - May 27 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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