Captivating capture: How microtubules attach to kinetochores

Sue Biggins, Claire Walczak

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Accurate chromosome segregation is essential to ensure genomic stability because the aneuploidy that results from segregation errors leads to birth defects and contributes to the development of cancer. Chromosome segregation is directed by the kinetochore, the chromosomal site of attachment to dynamic polymers called microtubules (MTs). Although the fidelity of chromosome segregation depends on precise interactions between kinetochores and MTs, it is still unclear how this interaction is mediated and regulated. Here we discuss current progress in determining how kinetochores assemble and attach to MTs during mitosis as well as how they correct errors.

Original languageEnglish
JournalCurrent Biology
Volume13
Issue number11
DOIs
StatePublished - May 27 2003

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Kinetochores
kinetochores
Chromosome Segregation
chromosome segregation
Chromosomes
Microtubules
microtubules
Genomic Instability
aneuploidy
Aneuploidy
Mitosis
mitosis
polymers
Polymers
genomics
Defects
neoplasms
Neoplasms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Captivating capture : How microtubules attach to kinetochores. / Biggins, Sue; Walczak, Claire.

In: Current Biology, Vol. 13, No. 11, 27.05.2003.

Research output: Contribution to journalArticle

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