Carba prostacyclin enhances the capsaicin-induced cobalt-loading of rat sensory neurons grown in culture

C. M. Hingtgen, G. D. Nicol

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Sensory neurons isolated from the dorsal root ganglia of embryonic rats and grown in culture are distributed into two populations based on cross-sectional areas and sensitivity to capsaicin. Of the total neuronal population, about 48% of the neurons are labelled by cobalt in the presence of 1 μM capsaicin. The distribution of the small-sized neurons coincides with that of the capsaicin-cobaltlabelled neurons. When a lower concentration of capsaicin (100 nM) is used, pretreatment of sensory neurons with carba prostacyclin, a stable analog of prostaglandin I2, produces a three-fold enhancement in the number of neurons that are cobalt-labelled by capsaicin compared with that in the absence of carba prostacyclin.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Volume173
Issue number1-2
DOIs
StatePublished - May 23 1994

Keywords

  • Capsaicin
  • Cobalt-loading
  • Prostaglandin
  • Sensitization
  • Sensory neuron

ASJC Scopus subject areas

  • Neuroscience(all)

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