Carbamazepine Maintenance Treatment in Outpatient Schizophrenics

William T. Carpenter, Rose Kurz, Brian Kirkpatrick, Thomas E. Hanlon, Ann T. Summerfelt, Robert W. Buchanan, Royce W. Waltrip, Alan Breier

Research output: Contribution to journalArticle

26 Scopus citations


A double-blind crossover trial was used to evaluate Carbamazepine as the sole maintenance treatment of chronic, nonmanic schizophrenic outpatients whose conditions had been stabilized with the use of neuroleptics prior to study. Criteria of treatment effectiveness included the number of patients relapsing and time to relapse over a 95-day neuroleptic-free period during which either carbamazepine or placebo was administered. Relapse was determined by the concordance of psychiatric ratings and independent clinical judgments indicating significant worsening. Results for 27 patients (13 receiving carbamazepine and 14 receiving placebo) involved in the first phase of this treatment comparison were nondifferentiating. Corroborating descriptive findings in the second phase were available for 14 of these patients. There was no evidence supporting the existence of a treatment-relevant subgroup defined by eqisodic dyscontrol phenomena.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalArchives of general psychiatry
Issue number1
StatePublished - Jan 1991
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Carpenter, W. T., Kurz, R., Kirkpatrick, B., Hanlon, T. E., Summerfelt, A. T., Buchanan, R. W., Waltrip, R. W., & Breier, A. (1991). Carbamazepine Maintenance Treatment in Outpatient Schizophrenics. Archives of general psychiatry, 48(1), 69-72.