Carbomer and sodium hyaluronate eyedrops for moderate dry eye treatment

Michael Edward Johnson, Paul James Murphy, Mike Boulton

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PURPOSE.: This randomized, double-masked study compared the effectiveness of two commercially available ocular lubricants containing either 0.3% Carbomer 934 or 0.18% sodium hyaluronate (SH) in treating moderate dry eye. METHODS.: Sixty-five subjects with dry eye were recruited and supplied with eyedrops containing either Carbomer or SH to use for a month. Principle outcome measures were the severity of symptoms of ocular irritation, tear break-up time without (NIBUT) and with (TBUT) fluorescein, and corneal and conjunctival staining with fluorescein and lissamine green, respectively. At the end of the experiment, subjects were also asked, on average, how many times a day they used the treatment and the duration of any postinstillation blur. RESULTS.: Both Carbomer and SH reduced the symptom severity and ocular surface staining, but neither had a lasting effect on NIBUT or TBUT. The treatment effects of Carbomer and SH were equivalent for symptoms, NIBUT and TBUT. However, for both corneal and conjunctival staining, SH outperformed Carbomer in improving the integrity of the ocular surface. There was no difference in the average instillation frequency of the two products. Visual disturbance after instillation of either formulation was generally short, but lengthy periods of blur were significantly more common after the use of Carbomer. CONCLUSIONS.: Both of the eyedrops trialled are suitable for patients with moderate dry eye, but of the two, the SH-containing treatment has marginal benefits in therapeutic efficacy and has less propensity to cause visual disturbance.

Original languageEnglish (US)
Pages (from-to)750-757
Number of pages8
JournalOptometry and Vision Science
Volume85
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Ophthalmic Solutions
Hyaluronic Acid
carbopol 940
Staining and Labeling
Fluorescein
Therapeutics
Lubricants
carbomer
Tears
Double-Blind Method
Outcome Assessment (Health Care)

Keywords

  • Artificial tears
  • Carbomer
  • Dry eye
  • Ocular comfort index
  • Ocular lubricants
  • Sodium hyaluronate
  • Tear substitutes

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Carbomer and sodium hyaluronate eyedrops for moderate dry eye treatment. / Johnson, Michael Edward; Murphy, Paul James; Boulton, Mike.

In: Optometry and Vision Science, Vol. 85, No. 8, 08.2008, p. 750-757.

Research output: Contribution to journalArticle

Johnson, Michael Edward ; Murphy, Paul James ; Boulton, Mike. / Carbomer and sodium hyaluronate eyedrops for moderate dry eye treatment. In: Optometry and Vision Science. 2008 ; Vol. 85, No. 8. pp. 750-757.
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