Carbon tetrachloride and the sorbitol pathway in the diabetic mouse

Bruce I. Gaynes, John B. Watkins

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

1. 1. Sorbitol dehydrogenase activity and the hepatic and serum concentrations of sorbitol, glucose and fructose were quantified in diabetic mice. 2. 2. Blood glucose concentrations were increased over 300% by diabetes and were decreased toward normal after insulin-treatment. 3. 3. Hepatic sorbitol concentrations ranged from 7-15 μmol/g and were highest in uncontrolled diabetic mice. 4. 4. Hepatic concentrations of fructose and sorbitol were not affected by insulin administration. 5. 5. Challenge with carbon tetrachloride (25 μl/kg i.p.) did not alter concentratiions of glucose, sorbitol or fructose in blood or liver. 6. 6. Sorbitol dehydrogenase activity in blood was increased similarly in normal, diabetic and insulin-treated diabetic mice after CCl4 administration. 7. 7. The data indicate that sorbitol did not accumulate in diabetic mice, and that induction of diabetes did not increase the susceptibility of mice to CCl4 hepatotoxicity as occurs in rats.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume94
Issue number1
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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