Carcinoid tumors of the urinary bladder. Immunohistochemical study of 2 cases and review of the literature.

Guido Martignoni, John N. Eble

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

We report the clinical, histopathologic, and immunophenotypic features of 2 carcinoid tumors of the urinary bladder and review the literature. Both tumors were located in the bladder neck, presented with hematuria, were small, and appeared to be completely excised cystoscopically. The tumors were smooth-surfaced sessile polypoid nodules covered by urothelium. Both tumors had glandular architecture. One tumor had regular bland nuclei, and the other had focal moderate nuclear pleomorphism. Neuroendocrine differentiation was readily confirmed by the immunohistochemical markers chromogranin, synaptophysin, and neural cell adhesion molecule (CD56/NCAM). In 1 of the tumors, 20% of the cells were positive for the beta subunit of human chorionic gonadotropin, and 20% were positive for thyroid transcription factor 1.

Original languageEnglish (US)
Pages (from-to)e22-24
JournalArchives of pathology & laboratory medicine
Volume127
Issue number1
StatePublished - Jan 2003
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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