Carcinoma of the cervix treated with chemotherapy and radiation therapy: Cooperative studies in the Gynecologic Oncology Group

Frederick Stehman, B. N. Bundy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Since its inception in 1970, the Gynecologic Oncology Group (GOG) has pursued a series of Phase II and III cooperative clinical investigations of the combination of cytotoxic chemotherapy and radiation therapy for patients with locally advanced carcinoma of the cervix. After an initial randomized trial indicated that hydroxyurea was superior to placebo, subsequent studies have evaluated whether the hypoxic sensitizer, misonidazole, or the combination of cisplatin with infusional 5-fluorouracil were superior to hydroxyurea. Other studies have evaluated concurrent chemotherapy with extended field radiation for patients with metastatic disease in their paraaortic nodes. The GOG will continue to attempt to identify and develop superior adjuncts to radiation therapy for this patient population.

Original languageEnglish
Pages (from-to)1697-1701
Number of pages5
JournalCancer
Volume71
Issue number4 SUPPL.
StatePublished - 1993

Fingerprint

Cervix Uteri
Radiotherapy
Hydroxyurea
Carcinoma
Drug Therapy
Misonidazole
Combination Drug Therapy
Fluorouracil
Cisplatin
Placebos
Radiation
Population

Keywords

  • cervical cancer
  • chemoradiation
  • hydroxyurea
  • radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Carcinoma of the cervix treated with chemotherapy and radiation therapy : Cooperative studies in the Gynecologic Oncology Group. / Stehman, Frederick; Bundy, B. N.

In: Cancer, Vol. 71, No. 4 SUPPL., 1993, p. 1697-1701.

Research output: Contribution to journalArticle

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