Carcinoma of the cervix treated with radiation therapy I

A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group

Frederick Stehman, B. N. Bundy, P. J. DiSaia, H. M. Keys, J. E. Larson, W. C. Fowler

Research output: Contribution to journalArticle

352 Citations (Scopus)

Abstract

Between 1977 and 1985, the Gynecologic Oncology Group (GOG) conducted three clinical trials in locally advanced carcinoma of the cervix, clinical Stages I to IV A as classified by the International Federation of Gynecology and Obstetrics (FIGO). All 626 patients had primary carcinoma of the cervix and underwent operative assessment of the para-aortic (PA) lymph nodes. Patients received standardized external radiation therapy to the pelvis or to the pelvis and PA lymph nodes followed by one or two brachytherapy applications. To date, no statistically significant differences in progression-free interval (PFI) or survival time have been identified between the randomization treatment arms on any of these studies. Basic similarities among these studies led us to pool these data to identify patient characteristics and tumor characteristics associated with an increased risk of treatment failure. Multi-variate analysis showed patient age, performance status (PS), PA lymph node status, tumor size, and pelvic node status to be significantly associated with PFI. When modeling for survival, all these factors and clinical stage and bilateral extension were significant.

Original languageEnglish (US)
Pages (from-to)2776-2785
Number of pages10
JournalCancer
Volume67
Issue number11
StatePublished - 1991

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Cervix Uteri
Radiotherapy
Carcinoma
Lymph Nodes
Pelvis
Survival
Brachytherapy
Random Allocation
Treatment Failure
Gynecology
Obstetrics
Neoplasms
Arm
Clinical Trials
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

Stehman, F., Bundy, B. N., DiSaia, P. J., Keys, H. M., Larson, J. E., & Fowler, W. C. (1991). Carcinoma of the cervix treated with radiation therapy I: A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer, 67(11), 2776-2785.

Carcinoma of the cervix treated with radiation therapy I : A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. / Stehman, Frederick; Bundy, B. N.; DiSaia, P. J.; Keys, H. M.; Larson, J. E.; Fowler, W. C.

In: Cancer, Vol. 67, No. 11, 1991, p. 2776-2785.

Research output: Contribution to journalArticle

Stehman, Frederick ; Bundy, B. N. ; DiSaia, P. J. ; Keys, H. M. ; Larson, J. E. ; Fowler, W. C. / Carcinoma of the cervix treated with radiation therapy I : A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. In: Cancer. 1991 ; Vol. 67, No. 11. pp. 2776-2785.
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