Carcinoma of the vulva

Frederick Stehman, Katherine Y. Look

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The objective of this review is to summarize the published data about squamous carcinoma of the vulva and to identify promising areas for future investigation. Rather than the routine use of complete radical vulvectomy, a radical wide excision of the vulvar lesion to achieve at least a 1-cm gross margin appears sufficient to treat the primary lesion. A surgical assessment of the groin is required for all patients who have invasion greater than 1 mm. Ipsilateral groin node dissection can be performed through a separate incision. All the nodal tissue medial to the vessels and above the fascia should be removed. Sentinel node evaluation may be a significant step forward, but the false-negative rate is not well enough defined to consider this a standard. Patients with positive inguinal nodes at groin dissection should receive radiation therapy to the ipsilateral groin and hemipelvis. For those patients who have unresectable primary disease or if nodes are palpably suspicious, fixed, and/or ulcerated preoperatively, chemoradiation is the preferred option. Exenterative procedures may rarely be required. Chemotherapy for recurrent or metastatic disease has not been proven to be of value. Although survival rates are high for those with negative nodes, the morbidity associated with standard radical techniques has prompted innovation. Adequately powered trials aimed at further reducing morbidity without compromising survival are underway.

Original languageEnglish
Pages (from-to)719-733
Number of pages15
JournalObstetrics and Gynecology
Volume107
Issue number3
DOIs
StatePublished - Mar 2006

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Vulva
Groin
Carcinoma
Dissection
Morbidity
Fascia
Squamous Cell Carcinoma
Radiotherapy
Survival Rate
Drug Therapy
Survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Carcinoma of the vulva. / Stehman, Frederick; Look, Katherine Y.

In: Obstetrics and Gynecology, Vol. 107, No. 3, 03.2006, p. 719-733.

Research output: Contribution to journalArticle

Stehman, Frederick ; Look, Katherine Y. / Carcinoma of the vulva. In: Obstetrics and Gynecology. 2006 ; Vol. 107, No. 3. pp. 719-733.
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