Cardiac autonomic dysfunction in patients with normal tension glaucoma: 24-h heart rate and blood pressure variability analysis

Joanna Wierzbowska, Robert Wierzbowski, Andrzej Stankiewicz, Brent Siesky, Alon Harris

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Aims: To define parameters of autonomic nervous system activity in patients with normal tension glaucoma (NTG). Methods: Ambulatory 24-h ECG (Lifecard CF) and 24-h blood pressure (BP) monitoring (SpaceLab 90207-30) were carried out in 54 patients with NTG (44 women, mean age 59.7) and 43 matched control subjects (34 women, mean age 57.0). Heart rate variability time and frequency domain parameters (low frequency (LF), high frequency (HF) and LF/HF ratio), BP variability (BPV), diurnal and nocturnal BP variables were compared between study groups. Results: Patients with NTG demonstrated higher LF, LF/HF and lower HF values than control subjects for the 24-h, daytime and night-time periods. The mean 24-h, daytime and night-time LF/HF ratios were statistically higher in patients with glaucoma as compared to control subjects ((3.2±1.5 vs 2.2±0.8, p=0.0009), (3.5±1.7 vs 2.7±1.0, p=0.0173) and (2.6±1.7 vs 1.4±0.6, p=0.0001), respectively). There were no statistical differences in the mean BP during the whole day, daytime and night-time, and in BPV (10.4±1.9 vs 10.5±2.1, p=0.790) between study groups. No difference was also found in the percentage decrease in night-time mean BP (12.3% vs 13.6%, p=0.720). 'Dippers', 'non-dippers' and 'overdippers' with NTG showed significantly higher LF/HF ratio as compared to the same subgroups of control subjects. Conclusions: The sympathovagal balance of autonomic nervous system in patients with NTG shifted towards sympathetic activity however with no change of 24-h pattern of BPV as compared to controls.

Original languageEnglish
Pages (from-to)624-628
Number of pages5
JournalBritish Journal of Ophthalmology
Volume96
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Low Tension Glaucoma
Heart Rate
Blood Pressure
Autonomic Nervous System
Glaucoma
Electrocardiography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Cardiac autonomic dysfunction in patients with normal tension glaucoma : 24-h heart rate and blood pressure variability analysis. / Wierzbowska, Joanna; Wierzbowski, Robert; Stankiewicz, Andrzej; Siesky, Brent; Harris, Alon.

In: British Journal of Ophthalmology, Vol. 96, No. 5, 05.2012, p. 624-628.

Research output: Contribution to journalArticle

@article{ff5e18d877c247baa257f37bd17f9c87,
title = "Cardiac autonomic dysfunction in patients with normal tension glaucoma: 24-h heart rate and blood pressure variability analysis",
abstract = "Aims: To define parameters of autonomic nervous system activity in patients with normal tension glaucoma (NTG). Methods: Ambulatory 24-h ECG (Lifecard CF) and 24-h blood pressure (BP) monitoring (SpaceLab 90207-30) were carried out in 54 patients with NTG (44 women, mean age 59.7) and 43 matched control subjects (34 women, mean age 57.0). Heart rate variability time and frequency domain parameters (low frequency (LF), high frequency (HF) and LF/HF ratio), BP variability (BPV), diurnal and nocturnal BP variables were compared between study groups. Results: Patients with NTG demonstrated higher LF, LF/HF and lower HF values than control subjects for the 24-h, daytime and night-time periods. The mean 24-h, daytime and night-time LF/HF ratios were statistically higher in patients with glaucoma as compared to control subjects ((3.2±1.5 vs 2.2±0.8, p=0.0009), (3.5±1.7 vs 2.7±1.0, p=0.0173) and (2.6±1.7 vs 1.4±0.6, p=0.0001), respectively). There were no statistical differences in the mean BP during the whole day, daytime and night-time, and in BPV (10.4±1.9 vs 10.5±2.1, p=0.790) between study groups. No difference was also found in the percentage decrease in night-time mean BP (12.3{\%} vs 13.6{\%}, p=0.720). 'Dippers', 'non-dippers' and 'overdippers' with NTG showed significantly higher LF/HF ratio as compared to the same subgroups of control subjects. Conclusions: The sympathovagal balance of autonomic nervous system in patients with NTG shifted towards sympathetic activity however with no change of 24-h pattern of BPV as compared to controls.",
author = "Joanna Wierzbowska and Robert Wierzbowski and Andrzej Stankiewicz and Brent Siesky and Alon Harris",
year = "2012",
month = "5",
doi = "10.1136/bjophthalmol-2011-300945",
language = "English",
volume = "96",
pages = "624--628",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Cardiac autonomic dysfunction in patients with normal tension glaucoma

T2 - 24-h heart rate and blood pressure variability analysis

AU - Wierzbowska, Joanna

AU - Wierzbowski, Robert

AU - Stankiewicz, Andrzej

AU - Siesky, Brent

AU - Harris, Alon

PY - 2012/5

Y1 - 2012/5

N2 - Aims: To define parameters of autonomic nervous system activity in patients with normal tension glaucoma (NTG). Methods: Ambulatory 24-h ECG (Lifecard CF) and 24-h blood pressure (BP) monitoring (SpaceLab 90207-30) were carried out in 54 patients with NTG (44 women, mean age 59.7) and 43 matched control subjects (34 women, mean age 57.0). Heart rate variability time and frequency domain parameters (low frequency (LF), high frequency (HF) and LF/HF ratio), BP variability (BPV), diurnal and nocturnal BP variables were compared between study groups. Results: Patients with NTG demonstrated higher LF, LF/HF and lower HF values than control subjects for the 24-h, daytime and night-time periods. The mean 24-h, daytime and night-time LF/HF ratios were statistically higher in patients with glaucoma as compared to control subjects ((3.2±1.5 vs 2.2±0.8, p=0.0009), (3.5±1.7 vs 2.7±1.0, p=0.0173) and (2.6±1.7 vs 1.4±0.6, p=0.0001), respectively). There were no statistical differences in the mean BP during the whole day, daytime and night-time, and in BPV (10.4±1.9 vs 10.5±2.1, p=0.790) between study groups. No difference was also found in the percentage decrease in night-time mean BP (12.3% vs 13.6%, p=0.720). 'Dippers', 'non-dippers' and 'overdippers' with NTG showed significantly higher LF/HF ratio as compared to the same subgroups of control subjects. Conclusions: The sympathovagal balance of autonomic nervous system in patients with NTG shifted towards sympathetic activity however with no change of 24-h pattern of BPV as compared to controls.

AB - Aims: To define parameters of autonomic nervous system activity in patients with normal tension glaucoma (NTG). Methods: Ambulatory 24-h ECG (Lifecard CF) and 24-h blood pressure (BP) monitoring (SpaceLab 90207-30) were carried out in 54 patients with NTG (44 women, mean age 59.7) and 43 matched control subjects (34 women, mean age 57.0). Heart rate variability time and frequency domain parameters (low frequency (LF), high frequency (HF) and LF/HF ratio), BP variability (BPV), diurnal and nocturnal BP variables were compared between study groups. Results: Patients with NTG demonstrated higher LF, LF/HF and lower HF values than control subjects for the 24-h, daytime and night-time periods. The mean 24-h, daytime and night-time LF/HF ratios were statistically higher in patients with glaucoma as compared to control subjects ((3.2±1.5 vs 2.2±0.8, p=0.0009), (3.5±1.7 vs 2.7±1.0, p=0.0173) and (2.6±1.7 vs 1.4±0.6, p=0.0001), respectively). There were no statistical differences in the mean BP during the whole day, daytime and night-time, and in BPV (10.4±1.9 vs 10.5±2.1, p=0.790) between study groups. No difference was also found in the percentage decrease in night-time mean BP (12.3% vs 13.6%, p=0.720). 'Dippers', 'non-dippers' and 'overdippers' with NTG showed significantly higher LF/HF ratio as compared to the same subgroups of control subjects. Conclusions: The sympathovagal balance of autonomic nervous system in patients with NTG shifted towards sympathetic activity however with no change of 24-h pattern of BPV as compared to controls.

UR - http://www.scopus.com/inward/record.url?scp=84860217248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860217248&partnerID=8YFLogxK

U2 - 10.1136/bjophthalmol-2011-300945

DO - 10.1136/bjophthalmol-2011-300945

M3 - Article

C2 - 22399689

AN - SCOPUS:84860217248

VL - 96

SP - 624

EP - 628

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 5

ER -