Cardiac Hypertrophy in Spontaneously Hypertensive Rats: Vectorcardiographic Investigation of Myocardial Depolarization (QRS-Loop)

V. A. Petrukhina, A. Y. Postnov, M. V. Zaretskaja, D. V. Zaretsky, V. E. Trapezin, N. A. Medvedeva

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The aim of our work was vectorcardiographic study of myocardial depolarisation in genetically predisposed to spontaneous hypertension rats. Spontaneously hypertensive rats (SHR), normotensive animals (WKY) and F1 and F2 hybrids of SHR×WKY intercross were used. Arterial blood pressure (BP), cardiac electrical activity (evaluated by vectorcardiography) and heart morphometry were studied in 144 animals. SHR, WKY and F1 and F2 hybrid male animals demonstrated following levels of systolic BP: 193±5, 139±3, 163±2, 164±2 mm Hg, respectively. Heart and left ventricular weights in F1 and F2 male rats were significantly different from those in SHR and WKY males. In all groups females compared with males of the same group had similar values of BP, but decreased values of body and heart weights. Vectorcardiography analysis demonstrated differences in direction of maximal QRS vector, terminal part of maximal QRS and the loop's width between SHR and WKY rats. Moreover, same differences were found between either of these groups and F1 and F2 animals. In F2 hybrids, values of BP were not in correlation with morphological data of the hearts. On the contrary, a close correlation between characteristics of QRS vector and heart or left ventricular weight was demonstrated for both sexes. These data indicate that: 1) according to vectorcardiography, ventricular depolarisation in F1 and F2 hybrids are similar to that in WKY rats despite cardiac hypertrophy in hybrid groups; 2) in F2 hybrids, vectorcardiographic parameters significantly correlate with myocardial weight, but not with BP.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalKardiologiya
Volume40
Issue number11
StatePublished - Dec 1 2000
Externally publishedYes

Keywords

  • Hypertrophic cardiomyopathy
  • Second generation hybrids
  • Spontaneously hypertensive rats
  • Vectorcardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Petrukhina, V. A., Postnov, A. Y., Zaretskaja, M. V., Zaretsky, D. V., Trapezin, V. E., & Medvedeva, N. A. (2000). Cardiac Hypertrophy in Spontaneously Hypertensive Rats: Vectorcardiographic Investigation of Myocardial Depolarization (QRS-Loop). Kardiologiya, 40(11), 33-39.