Cardiac repair by embryonic stem-derived cells

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Cell transplantation approaches offer the potential to promote regenerative growth of diseased hearts. It is well established that donor cardiomyocytes stably engraft into recipient hearts when injected directly into the myocardial wall. Moreover, the transplanted donor cardiomyocytes participate in a functional syncytium with the host myocardium. Thus, transplantation of donor cardiomyocytes resulted in at least partial restoration of lost muscle mass. It is also well established that embryonic stem (ES) cells differentiate into cells of ecto-, endo-, and mesodermal lineages when cultured under appropriate conditions in vitro. Robust cardiomyogenic differentiation was frequently observed in spontaneously differentiating ES cultures. Cellular, molecular and physiologic analyses indicated that ES-derived cells were bona fide cardiomyocytes, with in vitro characteristics typical for cells obtained from early stages of cardiac development. Thus, ES-derived cardiomyocytes constitute a viable source of donor cells for cell transplantation therapies.

Original languageEnglish (US)
Title of host publicationStem Cells
EditorsAnna M. Wobus, Kenneth Boheler, Kenneth R. Boheler
Pages73-100
Number of pages28
DOIs
StatePublished - Dec 1 2006

Publication series

NameHandbook of Experimental Pharmacology
Volume174
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

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Keywords

  • Cardiac regeneration
  • Cardiomyocytes
  • Cell transplantation
  • Embryonic stem cell
  • Heart disease

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry

Cite this

Rubart, M., & Field, L. J. (2006). Cardiac repair by embryonic stem-derived cells. In A. M. Wobus, K. Boheler, & K. R. Boheler (Eds.), Stem Cells (pp. 73-100). (Handbook of Experimental Pharmacology; Vol. 174). https://doi.org/10.1007/3-540-31265-X-4