Cardiac transplantation in infants and children

Mark Turrentine, Kenneth Kesler, Randall Caldwell, Robert Darragh, Lynda Means, Yousuf Mahomed, John Brown

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cardiac transplantation has become a more frequently used therapeutic modality for select cardiac pathology in infants and children. Since June 1986, 30 pediatric patients (19 male and 11 female) ranging in age from 4 days to 15 years (11 ≤ 1 month old) have undergone orthotopic cardiac transplantation at our institution. Indications included idiopathic cardiomyopathy (n = 8), hypoplastic left heart syndrome (n = 13), and other forms of complex congenital heart disease (n = 9). There have been four operative and three late deaths only in the groups with hypoplastic left heart syndrome and other forms of complex congenital heart disease. Cumulative survival is 77% after a mean follow-up of 30 months (range, 6 to 77 months). Three operative deaths were attributable to pulmonary hypertension, and the other was due to pulmonary hemorrhage. Two late deaths were secondary to allograft rejection, and the third was due to infection. There has been uniform survival in the group with idiopathic cardiomyopathy, and intermediate-term survival rates are 78% and 62% in the groups with complex congenital heart diseases and hypoplastic left heart syndrome, respectively (p = 0.15). Although longer-term results are necessary, orthotopic cardiac transplantation appears to be an acceptable mode of therapy for end-stage heart disease in the pediatric age group and technically can be performed despite complex malformations of the great arteries or atria.

Original languageEnglish
Pages (from-to)546-554
Number of pages9
JournalAnnals of Thoracic Surgery
Volume57
Issue number3
DOIs
StatePublished - 1994

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Heart Transplantation
Hypoplastic Left Heart Syndrome
Heart Diseases
Cardiomyopathies
Pediatrics
Survival
Pulmonary Hypertension
Allografts
Survival Rate
Arteries
Age Groups
Pathology
Hemorrhage
Lung
Therapeutics
Infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Cardiac transplantation in infants and children. / Turrentine, Mark; Kesler, Kenneth; Caldwell, Randall; Darragh, Robert; Means, Lynda; Mahomed, Yousuf; Brown, John.

In: Annals of Thoracic Surgery, Vol. 57, No. 3, 1994, p. 546-554.

Research output: Contribution to journalArticle

Turrentine, Mark ; Kesler, Kenneth ; Caldwell, Randall ; Darragh, Robert ; Means, Lynda ; Mahomed, Yousuf ; Brown, John. / Cardiac transplantation in infants and children. In: Annals of Thoracic Surgery. 1994 ; Vol. 57, No. 3. pp. 546-554.
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