Cardiac tumors and dysrhythmias in transgenic mice

M. E. Steinhelper, Loren Field

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed cardiac tumors asymmetrically in the right atrium. Features associated with cardiac failure, including increased plasma creatine kinase activity (MM and MB) and ventricular dysrhythmias, also were associated with atrial tumor growth. These atrial tumors were able to grow at histocompatible sites (subcutaneously in syngeneic animals) for protracted periods of time yielding a series of transplantable atrial tumor lineages. The transplantable tumors displayed several cardiac-specific characteristics, such as endogenous electrical activity and expression of cardiac-specific proteins. These transplantable atrial tumors constitute a novel experimental resource for developing cell lines which display an adult cardiac phenotype.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalToxicologic Pathology
Volume18
Issue number4 I
StatePublished - 1990
Externally publishedYes

Fingerprint

Heart Neoplasms
Transgenic Mice
Cardiac Arrhythmias
Tumors
Neoplasms
MM Form Creatine Kinase
Polyomavirus Transforming Antigens
MB Form Creatine Kinase
Gene Fusion
Atrial Natriuretic Factor
Heart Atria
Creatine Kinase
Heart Failure
Animals
Phenotype
Fusion reactions
Cell Line
Genes
Cells
Plasmas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cardiac tumors and dysrhythmias in transgenic mice. / Steinhelper, M. E.; Field, Loren.

In: Toxicologic Pathology, Vol. 18, No. 4 I, 1990, p. 464-469.

Research output: Contribution to journalArticle

Steinhelper, ME & Field, L 1990, 'Cardiac tumors and dysrhythmias in transgenic mice', Toxicologic Pathology, vol. 18, no. 4 I, pp. 464-469.
Steinhelper, M. E. ; Field, Loren. / Cardiac tumors and dysrhythmias in transgenic mice. In: Toxicologic Pathology. 1990 ; Vol. 18, No. 4 I. pp. 464-469.
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