Cardiac tumors and dysrhythmias in transgenic mice

M. E. Steinhelper, L. J. Field

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed cardiac tumors asymmetrically in the right atrium. Features associated with cardiac failure, including increased plasma creatine kinase activity (MM and MB) and ventricular dysrhythmias, also were associated with atrial tumor growth. These atrial tumors were able to grow at histocompatible sites (subcutaneously in syngeneic animals) for protracted periods of time yielding a series of transplantable atrial tumor lineages. The transplantable tumors displayed several cardiac-specific characteristics, such as endogenous electrical activity and expression of cardiac-specific proteins. These transplantable atrial tumors constitute a novel experimental resource for developing cell lines which display an adult cardiac phenotype.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalToxicologic Pathology
Volume18
Issue number4 I
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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