Cardiomyocyte DNA synthesis and binucleation during murine development

Mark Soonpaa, Kyung Keun Kim, Laura Pajak, Michael Franklin, Loren Field

Research output: Contribution to journalArticle

408 Citations (Scopus)

Abstract

Cardiomyocyte DNA synthesis and binucleation indexes were determined during murine development. Cardiomyocyte DNA synthesis occurred in two temporally distinct phases. The first phase occurred during fetal life and was associated exclusively with cardiomyocyte proliferation. The second phase occurred during early neonatal life and was associated with binucleation. Collectively, these results suggest that cardiomyocyte reduplication ceases during late fetal life. Northern and Western blot analyses identified several candidate genes that were differentially expressed during the reduplicative and binucleation phases of cardiomyocyte growth.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume40
Issue number5
StatePublished - Nov 1996

Fingerprint

Cardiac Myocytes
DNA
Northern Blotting
Western Blotting
Growth
Genes

Keywords

  • Cardiomyocyte reduplication
  • Cell cycle regulation

ASJC Scopus subject areas

  • Physiology

Cite this

Cardiomyocyte DNA synthesis and binucleation during murine development. / Soonpaa, Mark; Kim, Kyung Keun; Pajak, Laura; Franklin, Michael; Field, Loren.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 40, No. 5, 11.1996.

Research output: Contribution to journalArticle

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