Cardiovascular consequences of metabolic syndrome

Johnathan Tune, Adam G. Goodwill, Daniel J. Sassoon, Kieren Mather

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The metabolic syndrome (MetS) is defined as the concurrence of obesity-associated cardiovascular risk factors including abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, decreased HDL cholesterol, and/or hypertension. Earlier conceptualizations of the MetS focused on insulin resistance as a core feature, and it is clearly coincident with the above list of features. Each component of the MetS is an independent risk factor for cardiovascular disease and the combination of these risk factors elevates rates and severity of cardiovascular disease, related to a spectrum of cardiovascular conditions including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. While advances in understanding the etiology and consequences of this complex disorder have been made, the underlying pathophysiological mechanisms remain incompletely understood, and it is unclear how these concurrent risk factors conspire to produce the variety of obesity-associated adverse cardiovascular diseases. In this review, we highlight current knowledge regarding the pathophysiological consequences of obesity and the MetS on cardiovascular function and disease, including considerations of potential physiological and molecular mechanisms that may contribute to these adverse outcomes.

Original languageEnglish (US)
JournalTranslational Research
DOIs
StateAccepted/In press - Oct 21 2016

Fingerprint

Metabolic Syndrome X
Cardiovascular Diseases
Obesity
Heart Failure
Glucose Intolerance
Abdominal Obesity
Hypertriglyceridemia
HDL Cholesterol
Insulin Resistance
Coronary Artery Disease
Myocardial Infarction
Insulin
Hypertension
Glucose

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Cardiovascular consequences of metabolic syndrome. / Tune, Johnathan; Goodwill, Adam G.; Sassoon, Daniel J.; Mather, Kieren.

In: Translational Research, 21.10.2016.

Research output: Contribution to journalArticle

@article{a66eadd710fa468082652c637667485b,
title = "Cardiovascular consequences of metabolic syndrome",
abstract = "The metabolic syndrome (MetS) is defined as the concurrence of obesity-associated cardiovascular risk factors including abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, decreased HDL cholesterol, and/or hypertension. Earlier conceptualizations of the MetS focused on insulin resistance as a core feature, and it is clearly coincident with the above list of features. Each component of the MetS is an independent risk factor for cardiovascular disease and the combination of these risk factors elevates rates and severity of cardiovascular disease, related to a spectrum of cardiovascular conditions including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. While advances in understanding the etiology and consequences of this complex disorder have been made, the underlying pathophysiological mechanisms remain incompletely understood, and it is unclear how these concurrent risk factors conspire to produce the variety of obesity-associated adverse cardiovascular diseases. In this review, we highlight current knowledge regarding the pathophysiological consequences of obesity and the MetS on cardiovascular function and disease, including considerations of potential physiological and molecular mechanisms that may contribute to these adverse outcomes.",
author = "Johnathan Tune and Goodwill, {Adam G.} and Sassoon, {Daniel J.} and Kieren Mather",
year = "2016",
month = "10",
day = "21",
doi = "10.1016/j.trsl.2017.01.001",
language = "English (US)",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Cardiovascular consequences of metabolic syndrome

AU - Tune, Johnathan

AU - Goodwill, Adam G.

AU - Sassoon, Daniel J.

AU - Mather, Kieren

PY - 2016/10/21

Y1 - 2016/10/21

N2 - The metabolic syndrome (MetS) is defined as the concurrence of obesity-associated cardiovascular risk factors including abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, decreased HDL cholesterol, and/or hypertension. Earlier conceptualizations of the MetS focused on insulin resistance as a core feature, and it is clearly coincident with the above list of features. Each component of the MetS is an independent risk factor for cardiovascular disease and the combination of these risk factors elevates rates and severity of cardiovascular disease, related to a spectrum of cardiovascular conditions including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. While advances in understanding the etiology and consequences of this complex disorder have been made, the underlying pathophysiological mechanisms remain incompletely understood, and it is unclear how these concurrent risk factors conspire to produce the variety of obesity-associated adverse cardiovascular diseases. In this review, we highlight current knowledge regarding the pathophysiological consequences of obesity and the MetS on cardiovascular function and disease, including considerations of potential physiological and molecular mechanisms that may contribute to these adverse outcomes.

AB - The metabolic syndrome (MetS) is defined as the concurrence of obesity-associated cardiovascular risk factors including abdominal obesity, impaired glucose tolerance, hypertriglyceridemia, decreased HDL cholesterol, and/or hypertension. Earlier conceptualizations of the MetS focused on insulin resistance as a core feature, and it is clearly coincident with the above list of features. Each component of the MetS is an independent risk factor for cardiovascular disease and the combination of these risk factors elevates rates and severity of cardiovascular disease, related to a spectrum of cardiovascular conditions including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure. While advances in understanding the etiology and consequences of this complex disorder have been made, the underlying pathophysiological mechanisms remain incompletely understood, and it is unclear how these concurrent risk factors conspire to produce the variety of obesity-associated adverse cardiovascular diseases. In this review, we highlight current knowledge regarding the pathophysiological consequences of obesity and the MetS on cardiovascular function and disease, including considerations of potential physiological and molecular mechanisms that may contribute to these adverse outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85011269409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011269409&partnerID=8YFLogxK

U2 - 10.1016/j.trsl.2017.01.001

DO - 10.1016/j.trsl.2017.01.001

M3 - Article

C2 - 28130064

AN - SCOPUS:85011269409

JO - Translational Research

JF - Translational Research

SN - 1931-5244

ER -