Cardiovascular research in transgenic animals

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The ability to alter specifically the expression or activity of known gene products in intact animals provides a powerful experimental system to study pathophysiology. These animal models can now be readily generated using transgenic technology. Traditional transgenic approaches rely on gain-of-function alterations, and several experimental paradigms have recently been established based on this attribute. These include assessment of promoter function, overexpression of physiologically important gene products, targeted oncogenesis, and insertional mutagenesis. Technical and practical issues relevant to the generation of such models are discussed here. In addition, several recent transgenic models germane to the cardiovascular system are presented. These experiments provide exciting new model systems to study clinical issues that heretofore have been difficult, if not impossible, to address.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume1
Issue number4
DOIs
StatePublished - 1991

Fingerprint

Genetically Modified Animals
Insertional Mutagenesis
Cardiovascular System
Research
Genes
Carcinogenesis
Animal Models
Technology
Clinical Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiovascular research in transgenic animals. / Field, Loren.

In: Trends in Cardiovascular Medicine, Vol. 1, No. 4, 1991, p. 141-146.

Research output: Contribution to journalArticle

@article{1f468ca7e3a94686a76df86140916d82,
title = "Cardiovascular research in transgenic animals",
abstract = "The ability to alter specifically the expression or activity of known gene products in intact animals provides a powerful experimental system to study pathophysiology. These animal models can now be readily generated using transgenic technology. Traditional transgenic approaches rely on gain-of-function alterations, and several experimental paradigms have recently been established based on this attribute. These include assessment of promoter function, overexpression of physiologically important gene products, targeted oncogenesis, and insertional mutagenesis. Technical and practical issues relevant to the generation of such models are discussed here. In addition, several recent transgenic models germane to the cardiovascular system are presented. These experiments provide exciting new model systems to study clinical issues that heretofore have been difficult, if not impossible, to address.",
author = "Loren Field",
year = "1991",
doi = "10.1016/1050-1738(91)90018-A",
language = "English (US)",
volume = "1",
pages = "141--146",
journal = "Trends in Cardiovascular Medicine",
issn = "1050-1738",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Cardiovascular research in transgenic animals

AU - Field, Loren

PY - 1991

Y1 - 1991

N2 - The ability to alter specifically the expression or activity of known gene products in intact animals provides a powerful experimental system to study pathophysiology. These animal models can now be readily generated using transgenic technology. Traditional transgenic approaches rely on gain-of-function alterations, and several experimental paradigms have recently been established based on this attribute. These include assessment of promoter function, overexpression of physiologically important gene products, targeted oncogenesis, and insertional mutagenesis. Technical and practical issues relevant to the generation of such models are discussed here. In addition, several recent transgenic models germane to the cardiovascular system are presented. These experiments provide exciting new model systems to study clinical issues that heretofore have been difficult, if not impossible, to address.

AB - The ability to alter specifically the expression or activity of known gene products in intact animals provides a powerful experimental system to study pathophysiology. These animal models can now be readily generated using transgenic technology. Traditional transgenic approaches rely on gain-of-function alterations, and several experimental paradigms have recently been established based on this attribute. These include assessment of promoter function, overexpression of physiologically important gene products, targeted oncogenesis, and insertional mutagenesis. Technical and practical issues relevant to the generation of such models are discussed here. In addition, several recent transgenic models germane to the cardiovascular system are presented. These experiments provide exciting new model systems to study clinical issues that heretofore have been difficult, if not impossible, to address.

UR - http://www.scopus.com/inward/record.url?scp=0025868105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025868105&partnerID=8YFLogxK

U2 - 10.1016/1050-1738(91)90018-A

DO - 10.1016/1050-1738(91)90018-A

M3 - Article

VL - 1

SP - 141

EP - 146

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

SN - 1050-1738

IS - 4

ER -