Cardiovascular response to electrical stimulation of and microinjection of ouabain into posterior and ventromedial hypothalamus of cat

Subbiah Sivam, S. S. Seth, U. Nayar, S. C. Machanda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Electrical stimulation (ES) of and injection of ouabain into ventromedial hypothalamus (VMH) of cats elicited only minor changes in heart rate (HR) and blood pressure (BP). On the other hand similar treatments to posterior hypothalamus (PH) consistently produced a significant increase in HR and BP; two out of five animals developed cardiac arrhythmias. The study suggests that PH is a potential site of action of ouabain for induction of arrhythmias.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume33
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

Posterior Hypothalamus
Blood pressure
Microinjections
Ouabain
Electric Stimulation
Cardiac Arrhythmias
Cats
Heart Rate
Blood Pressure
Hypothalamus
Action Potentials
Animals
Injections
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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abstract = "Electrical stimulation (ES) of and injection of ouabain into ventromedial hypothalamus (VMH) of cats elicited only minor changes in heart rate (HR) and blood pressure (BP). On the other hand similar treatments to posterior hypothalamus (PH) consistently produced a significant increase in HR and BP; two out of five animals developed cardiac arrhythmias. The study suggests that PH is a potential site of action of ouabain for induction of arrhythmias.",
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AU - Seth, S. S.

AU - Nayar, U.

AU - Machanda, S. C.

PY - 1981

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