Cardioversion of atrial fibrillation with ibutilide: When is it most effective?

Mithilesh Das, Kurlwilla Cheriparambil, Ashwini Bedi, John Kassotis, Chatla V R Reddy, Barry Saul, Majesh Makan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Atrial fibrillation (AF) is found in 1% of persons above the age of 60 years. More than 5% of the population older than 69 years and about 14% of octogenarians are at risk for this arrhythmia. It is estimated that 1.5 to 3 million persons in the United States alone suffer from AF. The public health implications and attendant morbidity are a significant drain on our health care system. Hypothesis: The purpose of this study was to determine the clinical and echocardiographic predictors of success in converting AF of ≥ 24 h duration. Methods: Demographic and clinical and echocardiographic parameters of 101 patients with recent onset AF (>24 h) who received ibutilide were studied. Results: Of 101 patients, 56 (55%) converted to sinus rhythm. Age, gender, hypertension, diabetes mellitus, left ventricular ejection fraction (≤35%), congestive heart failure, and previous medication for rate control had no significant effect on the conversion rate. Conversion rate was only 30% (9/30 patients) in the presence of an enlarged left atrium (LA ≥ 5 cm) and 37.7% (23/61 patients) in the presence of mitral valve disease (MVD), whereas the conversion rate was 82.5% (33/40 patients) in the absence of MVD and 85% (29/34 patients) in the absence of both enlarged LA and MVD (p =

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalClinical Cardiology
Volume25
Issue number9
StatePublished - Sep 2002
Externally publishedYes

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Electric Countershock
Atrial Fibrillation
Mitral Valve
Heart Atria
Stroke Volume
ibutilide
Cardiac Arrhythmias
Diabetes Mellitus
Heart Failure
Public Health
Demography
Hypertension
Morbidity
Delivery of Health Care
Population

Keywords

  • Atrial fibrillation
  • Ibutilide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Das, M., Cheriparambil, K., Bedi, A., Kassotis, J., Reddy, C. V. R., Saul, B., & Makan, M. (2002). Cardioversion of atrial fibrillation with ibutilide: When is it most effective? Clinical Cardiology, 25(9), 411-415.

Cardioversion of atrial fibrillation with ibutilide : When is it most effective? / Das, Mithilesh; Cheriparambil, Kurlwilla; Bedi, Ashwini; Kassotis, John; Reddy, Chatla V R; Saul, Barry; Makan, Majesh.

In: Clinical Cardiology, Vol. 25, No. 9, 09.2002, p. 411-415.

Research output: Contribution to journalArticle

Das, M, Cheriparambil, K, Bedi, A, Kassotis, J, Reddy, CVR, Saul, B & Makan, M 2002, 'Cardioversion of atrial fibrillation with ibutilide: When is it most effective?', Clinical Cardiology, vol. 25, no. 9, pp. 411-415.
Das M, Cheriparambil K, Bedi A, Kassotis J, Reddy CVR, Saul B et al. Cardioversion of atrial fibrillation with ibutilide: When is it most effective? Clinical Cardiology. 2002 Sep;25(9):411-415.
Das, Mithilesh ; Cheriparambil, Kurlwilla ; Bedi, Ashwini ; Kassotis, John ; Reddy, Chatla V R ; Saul, Barry ; Makan, Majesh. / Cardioversion of atrial fibrillation with ibutilide : When is it most effective?. In: Clinical Cardiology. 2002 ; Vol. 25, No. 9. pp. 411-415.
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