Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases

Shih Te Tu, I-Wen Wang, Hsiu Fen Lin, Yi Chu Liao, Ruey Tay Lin, Chin San Liu, S. H H Juo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: We assessed the correlation between intima-media thickness (IMT) and stiffness and test whether they are independent risk factors for atherosclerotic diseases. Methods: We enrolled 2333 participants from the general population. Among the study subjects, 197 subjects had a history of stroke or myocardial infarction (MI) and were treated as patients, and the rest were the control subjects. Intima-media thickness was measured at the common carotid artery (CCA), bifurcation, and internal carotid artery. Three parameters (arterial stiffness [β], elastic modulus, and pulse wave velocity) were measured for carotid stiffness. Correlation between IMT and stiffness was first calculated. Multivariate regression model was used to evaluate whether inclusion of both IMT and stiffness can increase the prediction of cardiovascular events. Results: Only CCA and bifurcation IMTs were significantly and positively correlated with stiffness. After adjusting for age and sex, the correlations were substantially attenuated. Common carotid artery IMT was most significantly associated with stroke and MI (P = 2.6 × 10-8) followed by bifurcation IMT (P = 5.5 × 10-6), and internal carotid artery IMT was least significant (P = 0.02). For stiffness, β was most significant (P = 3.6 × 10-8) for stroke and MI, followed by elastic modulus (P= 1.1 × 10-6) and pulse wave velocity (P = 6.8 × 10-6). The best model for the combined effect was from β (P <0.03) and CCA (P = 0.056) or bifurcation IMT (P = 0.057). Conclusions: Carotid IMT and stiffness represent different properties of atherosclerotic vessel wall. Measuring both traits provides a better characterization of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)786-790
Number of pages5
JournalJournal of Investigative Medicine
Volume58
Issue number6
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Carotid Intima-Media Thickness
Common Carotid Artery
Stiffness
Pulse Wave Analysis
Elastic Modulus
Stroke
Myocardial Infarction
Internal Carotid Artery
Vascular Stiffness
Atherosclerosis
Elastic moduli
Population

Keywords

  • Carotid artery
  • Intima-media thickness
  • Stiffness

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases. / Tu, Shih Te; Wang, I-Wen; Lin, Hsiu Fen; Liao, Yi Chu; Lin, Ruey Tay; Liu, Chin San; Juo, S. H H.

In: Journal of Investigative Medicine, Vol. 58, No. 6, 08.2010, p. 786-790.

Research output: Contribution to journalArticle

Tu, Shih Te ; Wang, I-Wen ; Lin, Hsiu Fen ; Liao, Yi Chu ; Lin, Ruey Tay ; Liu, Chin San ; Juo, S. H H. / Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases. In: Journal of Investigative Medicine. 2010 ; Vol. 58, No. 6. pp. 786-790.
@article{849b3885bd3341b9b7c1766e13404c48,
title = "Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases",
abstract = "Objective: We assessed the correlation between intima-media thickness (IMT) and stiffness and test whether they are independent risk factors for atherosclerotic diseases. Methods: We enrolled 2333 participants from the general population. Among the study subjects, 197 subjects had a history of stroke or myocardial infarction (MI) and were treated as patients, and the rest were the control subjects. Intima-media thickness was measured at the common carotid artery (CCA), bifurcation, and internal carotid artery. Three parameters (arterial stiffness [β], elastic modulus, and pulse wave velocity) were measured for carotid stiffness. Correlation between IMT and stiffness was first calculated. Multivariate regression model was used to evaluate whether inclusion of both IMT and stiffness can increase the prediction of cardiovascular events. Results: Only CCA and bifurcation IMTs were significantly and positively correlated with stiffness. After adjusting for age and sex, the correlations were substantially attenuated. Common carotid artery IMT was most significantly associated with stroke and MI (P = 2.6 × 10-8) followed by bifurcation IMT (P = 5.5 × 10-6), and internal carotid artery IMT was least significant (P = 0.02). For stiffness, β was most significant (P = 3.6 × 10-8) for stroke and MI, followed by elastic modulus (P= 1.1 × 10-6) and pulse wave velocity (P = 6.8 × 10-6). The best model for the combined effect was from β (P <0.03) and CCA (P = 0.056) or bifurcation IMT (P = 0.057). Conclusions: Carotid IMT and stiffness represent different properties of atherosclerotic vessel wall. Measuring both traits provides a better characterization of atherosclerosis.",
keywords = "Carotid artery, Intima-media thickness, Stiffness",
author = "Tu, {Shih Te} and I-Wen Wang and Lin, {Hsiu Fen} and Liao, {Yi Chu} and Lin, {Ruey Tay} and Liu, {Chin San} and Juo, {S. H H}",
year = "2010",
month = "8",
doi = "10.231/JIM.0b013e3181e8019d",
language = "English (US)",
volume = "58",
pages = "786--790",
journal = "Journal of Investigative Medicine",
issn = "1081-5589",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Carotid intima-media thickness and stiffness are independent risk factors for atherosclerotic diseases

AU - Tu, Shih Te

AU - Wang, I-Wen

AU - Lin, Hsiu Fen

AU - Liao, Yi Chu

AU - Lin, Ruey Tay

AU - Liu, Chin San

AU - Juo, S. H H

PY - 2010/8

Y1 - 2010/8

N2 - Objective: We assessed the correlation between intima-media thickness (IMT) and stiffness and test whether they are independent risk factors for atherosclerotic diseases. Methods: We enrolled 2333 participants from the general population. Among the study subjects, 197 subjects had a history of stroke or myocardial infarction (MI) and were treated as patients, and the rest were the control subjects. Intima-media thickness was measured at the common carotid artery (CCA), bifurcation, and internal carotid artery. Three parameters (arterial stiffness [β], elastic modulus, and pulse wave velocity) were measured for carotid stiffness. Correlation between IMT and stiffness was first calculated. Multivariate regression model was used to evaluate whether inclusion of both IMT and stiffness can increase the prediction of cardiovascular events. Results: Only CCA and bifurcation IMTs were significantly and positively correlated with stiffness. After adjusting for age and sex, the correlations were substantially attenuated. Common carotid artery IMT was most significantly associated with stroke and MI (P = 2.6 × 10-8) followed by bifurcation IMT (P = 5.5 × 10-6), and internal carotid artery IMT was least significant (P = 0.02). For stiffness, β was most significant (P = 3.6 × 10-8) for stroke and MI, followed by elastic modulus (P= 1.1 × 10-6) and pulse wave velocity (P = 6.8 × 10-6). The best model for the combined effect was from β (P <0.03) and CCA (P = 0.056) or bifurcation IMT (P = 0.057). Conclusions: Carotid IMT and stiffness represent different properties of atherosclerotic vessel wall. Measuring both traits provides a better characterization of atherosclerosis.

AB - Objective: We assessed the correlation between intima-media thickness (IMT) and stiffness and test whether they are independent risk factors for atherosclerotic diseases. Methods: We enrolled 2333 participants from the general population. Among the study subjects, 197 subjects had a history of stroke or myocardial infarction (MI) and were treated as patients, and the rest were the control subjects. Intima-media thickness was measured at the common carotid artery (CCA), bifurcation, and internal carotid artery. Three parameters (arterial stiffness [β], elastic modulus, and pulse wave velocity) were measured for carotid stiffness. Correlation between IMT and stiffness was first calculated. Multivariate regression model was used to evaluate whether inclusion of both IMT and stiffness can increase the prediction of cardiovascular events. Results: Only CCA and bifurcation IMTs were significantly and positively correlated with stiffness. After adjusting for age and sex, the correlations were substantially attenuated. Common carotid artery IMT was most significantly associated with stroke and MI (P = 2.6 × 10-8) followed by bifurcation IMT (P = 5.5 × 10-6), and internal carotid artery IMT was least significant (P = 0.02). For stiffness, β was most significant (P = 3.6 × 10-8) for stroke and MI, followed by elastic modulus (P= 1.1 × 10-6) and pulse wave velocity (P = 6.8 × 10-6). The best model for the combined effect was from β (P <0.03) and CCA (P = 0.056) or bifurcation IMT (P = 0.057). Conclusions: Carotid IMT and stiffness represent different properties of atherosclerotic vessel wall. Measuring both traits provides a better characterization of atherosclerosis.

KW - Carotid artery

KW - Intima-media thickness

KW - Stiffness

UR - http://www.scopus.com/inward/record.url?scp=77958011177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958011177&partnerID=8YFLogxK

U2 - 10.231/JIM.0b013e3181e8019d

DO - 10.231/JIM.0b013e3181e8019d

M3 - Article

C2 - 20571440

AN - SCOPUS:77958011177

VL - 58

SP - 786

EP - 790

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

SN - 1081-5589

IS - 6

ER -