Cartilage degeneration in relation to repetitive pressure: Case study of a unilateral hip hemiarthroplasty patient

C. A. McGibbon, D. E. Krebs, C. A. Trahan, Stephen Trippel, R. W. Mann

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In vivo acetabular contact pressures were measured over 32 months in an elderly man with a pressure instrumented hemiarthroplasty. After death, left (hemiarthroplasty) and right (control) acetabula were explanted. Cartilage thickness and degeneration were quantified from magnetic resonance imaging and histological analysis. Highest repetitive in vivo contact pressures during gait (4.5 to 6.5 MPa) were measured in the superior dome of the acetabulum and decreased at a rate of approximately 1 MPa per year after implant (R2 = 0.48, P <.001). Contact pressure magnitudes measured during gait correlated positively with regional histology score (R2 = 0.34, P <.0001) and negatively with cartilage thickness (R2 = 0.35, P <.0001). Although histology scores were typical of early osteoarthritis (histological grade of 4-6), there were no significant differences in overall histology score for the left and right acetabula (P = .23). We conclude that acetabular cartilage degeneration was explained, in part, by repetitive stress, but the degeneration did not appear to be mediated solely by articulation with the metallic endoprosthesis.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalJournal of Arthroplasty
Volume14
Issue number1
DOIs
StatePublished - Jan 1999
Externally publishedYes

Fingerprint

Hemiarthroplasty
Acetabulum
Cartilage
Hip
Pressure
Histology
Gait
Pyridinolcarbamate
Osteoarthritis
Magnetic Resonance Imaging

Keywords

  • Acetabular cartilage
  • Cartilage degeneration
  • Hemiarthroplasty
  • Repetitive pressure

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Cartilage degeneration in relation to repetitive pressure : Case study of a unilateral hip hemiarthroplasty patient. / McGibbon, C. A.; Krebs, D. E.; Trahan, C. A.; Trippel, Stephen; Mann, R. W.

In: Journal of Arthroplasty, Vol. 14, No. 1, 01.1999, p. 52-58.

Research output: Contribution to journalArticle

McGibbon, C. A. ; Krebs, D. E. ; Trahan, C. A. ; Trippel, Stephen ; Mann, R. W. / Cartilage degeneration in relation to repetitive pressure : Case study of a unilateral hip hemiarthroplasty patient. In: Journal of Arthroplasty. 1999 ; Vol. 14, No. 1. pp. 52-58.
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