Case identification and stability of the deficit syndrome of schizophrenia

Brian Kirkpatrick, Robert W. Buchanan, Alan Breier, William T. Carpenter

Research output: Contribution to journalArticle

145 Scopus citations


In certain situations, such as large epidemiological studies, it may be necessary to use proxy case-identification tools instead of "gold-standard" assessments. The deficit syndrome of schizophrenia requires a clinical assessment that may not be feasible in some study populations. Measures for the discrimination of deficit and nondeficit patients, based on the Brief Psychiatric Rating Scale (BPRS), were assessed in a group of 100 outpatients with chronic schizophrenia. A rationally based case-identification tool was validated, and its case-identification properties were found to be stable over time; consequently, this proxy measure may be of use in other data sets. The stability of the relationship between this BPRS measure and the deficit/nondeficit categorization supports the view that it is a valid categorization.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalPsychiatry Research
Issue number1
StatePublished - Apr 1993
Externally publishedYes


  • Brief Psychiatric Rating Scale
  • Epidemiology
  • diagnosis
  • psychometrics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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