Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction

Raghuvar Dronamraju, Jenny L. Kerschner, Sarah A. Peck, Austin J. Hepperla, Alexander T. Adams, Katlyn D. Hughes, Sadia Aslam, Andrew R. Yoblinski, Ian J. Davis, Amber Mosley, Brian D. Strahl

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dronamraju et al. show that the N terminus of Spt6 is phosphorylated by casein kinase II, which is required for proper Spt6-Spn1 interaction. CKII phosphorylation of Spt6 is pivotal to maintain nucleosome occupancy at the 5′ ends of genes, suppression of antisense transcription from the 5′ ends, and resistance to genotoxic agents.

Original languageEnglish (US)
Pages (from-to)3476-3489.e5
JournalCell Reports
Volume25
Issue number12
DOIs
StatePublished - Dec 18 2018

Fingerprint

Casein Kinase II
Phosphorylation
Nucleosomes
Transcription
Genes

Keywords

  • CKII
  • nucleosome occupancy
  • SILAC
  • Spn1
  • Spt6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dronamraju, R., Kerschner, J. L., Peck, S. A., Hepperla, A. J., Adams, A. T., Hughes, K. D., ... Strahl, B. D. (2018). Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction. Cell Reports, 25(12), 3476-3489.e5. https://doi.org/10.1016/j.celrep.2018.11.089

Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction. / Dronamraju, Raghuvar; Kerschner, Jenny L.; Peck, Sarah A.; Hepperla, Austin J.; Adams, Alexander T.; Hughes, Katlyn D.; Aslam, Sadia; Yoblinski, Andrew R.; Davis, Ian J.; Mosley, Amber; Strahl, Brian D.

In: Cell Reports, Vol. 25, No. 12, 18.12.2018, p. 3476-3489.e5.

Research output: Contribution to journalArticle

Dronamraju, R, Kerschner, JL, Peck, SA, Hepperla, AJ, Adams, AT, Hughes, KD, Aslam, S, Yoblinski, AR, Davis, IJ, Mosley, A & Strahl, BD 2018, 'Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction', Cell Reports, vol. 25, no. 12, pp. 3476-3489.e5. https://doi.org/10.1016/j.celrep.2018.11.089
Dronamraju R, Kerschner JL, Peck SA, Hepperla AJ, Adams AT, Hughes KD et al. Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction. Cell Reports. 2018 Dec 18;25(12):3476-3489.e5. https://doi.org/10.1016/j.celrep.2018.11.089
Dronamraju, Raghuvar ; Kerschner, Jenny L. ; Peck, Sarah A. ; Hepperla, Austin J. ; Adams, Alexander T. ; Hughes, Katlyn D. ; Aslam, Sadia ; Yoblinski, Andrew R. ; Davis, Ian J. ; Mosley, Amber ; Strahl, Brian D. / Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction. In: Cell Reports. 2018 ; Vol. 25, No. 12. pp. 3476-3489.e5.
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